eISSN: 1509-572x
ISSN: 1641-4640
Folia Neuropathologica
Current issue Archive Manuscripts accepted About the journal Special Issues Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
4/2016
vol. 54
 
Share:
Share:
abstract:
Original paper

Alzheimer’s amyloid-β peptide disturbs P2X7 receptor-mediated circadian oscillations of intracellular calcium

Anna Wilkaniec
1, 2, 3
,
Karen Schmitt
1, 2
,
Amandine Grimm
1, 2
,
Joanna B. Strosznajder
3
,
Anne Eckert
1, 2

  1. Neurobiology Laboratory for Brain Aging and Mental Health, Transfaculty Research Platform, Molecular and Cognitive Neuroscience, University of Basel, Basel, Switzerland,
  2. Psychiatric University Clinics, University of Basel, Basel, Switzerland
  3. Mossakowski Medical Research Center, Polish Academy of Sciences, Department of Cellular Signaling, Warsaw, Poland
Folia Neuropathol 2016; 54 (4): 360-368
Online publish date: 2016/12/27
View full text Get citation
 
PlumX metrics:
Recent data indicate that Alzheimer’s disease (AD) is associated with disturbances of the circadian rhythm in patients. We examined the effect of amyloid-β (Aβ) peptide, the main component of the senile plaques playing a critical role in the deregulation of calcium (Ca2+) homeostasis in AD, on the circadian oscillation of cytosolic calcium (Ca2+) levels in vitro. The experiments we carried out in human primary skin fibroblasts. This cell line was previously shown to exhibit circadian rhythms of clock genes. Moreover, the basic clock properties of these peripheral cells closely mimic those measured physiologically and behaviorally in human and do not change during aging. In this study we showed that i) cytosolic Ca2+ oscillations depend on the activation of purinergic P2X7 receptors; and ii) these oscillations are abolished in the presence of Aβ. In total, our new findings may help to deepen our understanding of the molecular mechanisms involved in AD-related circadian alterations.
keywords:

amyloid-β, Alzheimer’s disease, calcium, P2X7 receptors, circadian rhythms

Quick links
© 2024 Termedia Sp. z o.o.
Developed by Bentus.