Current options and perspectives for the topical treatment
of atopic dermatitis

Roman Nowicki; Elżbieta Grubska-Suchanek; Magdalena Trzeciak; Aleksandra Wilkowska

doi:10.5114/dr.2021.107283

eISSN: 2084-9893
ISSN: 0033-2526

Dermatology Review/Przegląd Dermatologiczny

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2/2021
vol. 108

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abstract:

Review paper

Current options and perspectives for the topical treatment of atopic dermatitis

Roman J. Nowicki

¹

,

Elżbieta Grubska-Suchanek

¹

,

Magdalena Trzeciak

¹

,

Aleksandra Wilkowska

¹

Department of Dermatology, Venereology and Allergology, Medical University of Gdansk, Gdansk, Poland

Dermatol Rev/Przegl Dermatol 2021, 108, 117-125

DOI: https://doi.org/10.5114/dr.2021.107283

Online publish date: 2021/06/28

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Atopic dermatitis is one of the most common chronic and recurrent skin conditions, characterized by a complex genetic background, most commonly occurring in children. Its prevalence is still increasing. Despite existing methods of therapy (emollients, wet-wrap treatment, topical glucocorticoids, topical calcineurin inhibitors, antiseptics, antibiotics, phototherapy, elimination of irritants, patient education), the number of available topical preparations for the treatment of this chronic disease is limited. Topical glucocorticoids are the mainstay of the treatment of inflammatory changes. Calcineurin inhibitors should not be used under the age of two, and in the remaining patients, topical calcineurin inhibitors constitute the second-line therapy. Glucocorticoids can only be used for a strictly defined period of time and become gradually less effective during a long-term treatment (tachyphylaxis). Introduction of new, safe, topical preparations for the treatment of this chronic disease is imperative.

keywords:

Current options and perspectives for the topical treatment of atopic dermatitis

Roman J. Nowicki 1 , Elżbieta Grubska-Suchanek 1 , Magdalena Trzeciak 1 , Aleksandra Wilkowska 1

atopic dermatitis, wet-wrap treatment, crisaborole, JAK-STAT inhibitors

Roman J. Nowicki

¹

,

Elżbieta Grubska-Suchanek

¹

,

Magdalena Trzeciak

¹

,

Aleksandra Wilkowska

¹