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1/2024
vol. 62
 
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Original paper

Proinflammatory microglial response is a common mechanism of Aroclor 1254- and Tetrabromobisphenol-A-induced neurotoxicity in immature chronically exposed rats

Beata Dąbrowska-Bouta
1
,
Grzegorz Sulkowski
1
,
Małgorzata Frontczak-Baniewicz
2
,
Dorota Sulejczak
3
,
Lidia Strużyńska
1

1.
Laboratory of Pathoneurochemistry, Department of Neurochemistry, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland
2.
Electron Microscopy Research Unit, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland
3.
Department of Experimental Pharmacology, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland
Folia Neuropathol 2024; 62 (1): 1-12
Online publish date: 2024/03/29
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- Proinflammatory.pdf  [0.36 MB]
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1. Bell MR, Dryden A, Will R, Gore AC. Sex differences in effects of gestational polychlorinated biphenyl exposure on hypothalamic neuroimmune and neuromodulator systems in neonatal rats. Toxicol Appl Pharmacol 2018; 353: 55-66.
2. Chapman GA, Moores K, Harrison D, Campbell CA, Stewart BR, Strijbos PJ. Fractalkine cleavage from neuronal membranes represents an acute event in the inflammatory response to excitotoxic brain damage. J Neurosci 2000; 20: RC87.
3. Choi W, Eum SY, Lee YW, Hennig B, Robertson LW, Toborek M. PCB 104-induced proinflammatory reactions in human vascular endothelial cells: relationship to cancer metastasis and atherogenesis. Toxicol Sci 2003; 75: 47-56.
4. Choi YJ, Arzuaga X, Kluemper CT, Caraballo A, Toborek M, Hennig B. Quercetin blocks caveolae-dependent pro-inflammatory responses induced by co-planar PCBs. Environ Int 2010; 36: 931-934.
5. Eum SY, Lee YW, Hennig B, Toborek M. VEGF regulates PCB 104-mediated stimulation of permeability and transmigration of breast cancer cells in human microvascular endothelial cells. Exp Cell Res 2004; 296: 231-244.
6. Eze CT, Michelangeli F, Otitoloju AA, Eze OO, Ibraheem O, Ogbuene EB, Ogunwole GA. Occurrence of chemical pollutants in major e-waste sites in West Africa and usefulness of cytotoxicity and induction of ethoxyresorufin-O-deethylase (EROD) in determining the effects of some detected brominated flame retardants and e-waste soil-derived extracts. Environ Sci Pollut Res Int 2021; 28: 10832-10846.
7. Faroon O, Jones D, de Rosa C. Effects of polychlorinated biphenyls on the nervous system. Toxicol Ind Health 2000; 16: 305-333.
8. Felty Q, Yoo C, Kennedy A. Gene expression profile of endothelial cells exposed to estrogenic environmental compounds: implications to pulmonary vascular lesions. Life Sci 2010; 86: 919-927.
9. Fodelianaki G, Lansing F, Bhattarai P, Troullinaki M, Zeballos MA, Charalampopoulos I, Gravanis A, Mirtschink P, Chavakis T, Alexaki VI. Nerve Growth Factor modulates LPS-induced microglial glycolysis and inflammatory responses. Exp Cell Res 2019; 377: 10-16.
10. Gąssowska-Dobrowolska M, Chlubek M, Kolasa A, Tomasiak P, Korbecki J, Skowrońska K, Tarnowski M, Masztalewicz M, Baranowska-Bosiacka I. Microglia and astroglia-the potential role in neuroinflammation induced by pre- and neonatal exposure to lead (Pb). Int J Mol Sci 2023; 24: 9903.
11. González-Scarano F, Baltuch G, Microglia as mediators of inflammatory and degenerative diseases. Annu Rev Neurosci 1999; 22: 219-240.
12. Hamby ME, Sofroniew MV. Reactive astrocytes as therapeutic targets for CNS disorders. Neurotherapeutics 2010; 7: 494-506.
13. Hanisch UK. Microglia as a source and target of cytokines. Glia 2002; 40: 140-155.
14. Hayley S, Mangano E, Crowe G, Li N, Bowers WJ. An in vivo animal study assessing long-term changes in hypothalamic cytokines following perinatal exposure to a chemical mixture based on Arctic maternal body burden. Environ Health 2011; 10: 65.
15. Hilgier W, Łazarewicz JW, Strużynska L, Frontczak-Baniewicz M, Albrecht J. Repeated exposure of adult rats to Aroclor 1254 induces neuronal injury and impairs the neurochemical manifestations of the NMDA receptor-mediated intracellular signaling in the hippocampus. Neurotoxicology 2012; 33: 16-22.
16. Hirai T, Fujimine Y, Watanabe S, Nakano T. Distribution of polybrominated diphenyl ethers in Japanese autopsy tissue and body fluid samples. Environ Sci Pollut Res Int 2012; 19: 3538-3546.
17. Justo AFO, Suemoto CK. The modulation of neuroinflammation by inducible nitric oxide synthase. J Cell Commun Signal 2022; 16: 155-158.
18. Kim AH, Chun HJ, Lee S, Kim HS, Lee J. High dose tetrabromobisphenol A impairs hippocampal neurogenesis and memory retention. Food Chem Toxicol 2017; 106: 223-231.
19. Kim HY, Park CH, Park JB, Ko K, Lee MH, Chung J, Yoo YH. Hepatic STAMP2 alleviates polychlorinated biphenyl-induced steatosis and hepatic iron overload in NAFLD models. Environ Toxicol 2022; 37: 2223-2234.
20. Kwon O, Lee E, Moon TC, Jung H, Lin CX, Nam KS, Baek SH, Min HK, Chang HW. Expression of cyclooxygenase-2 and pro-inflammatory cytokines induced by 2,2’,4,4’,5,5’-hexachlorobiphenyl (PCB 153) in human mast cells requires NF-kappa B activation. Biol Pharm Bull 2002; 25: 1165-1168.
21. La Cava A. Leptin in inflammation and autoimmunity. Cytokine 2017; 98: 51-58.
22. Laden F, Neas LM, Spiegelman D, Hankinson SE, Willett WC, Ireland K, Wolff MS, Hunter DJ. Predictors of plasma concentrations of DDE and PCBs in a group of U.S. women. Environ Health Perspect 1999; 107: 75-81.
23. Liao Y, Gu Y, Wang J, Tian Y, Ni X, Zhou L, Ye Y, Xia G. HSF1 inhibits microglia activation to attenuate neuroinflammation via regulating miR-214-3p and NFATc2 in Parkinson’s disease. Folia Neuropathol 2023; 61: 53-67.
24. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951; 193: 265-275.
25. Majkova Z, Oesterling E, Toborek M, Hennig B. Impact of nutrition on PCB toxicity. Environ. Toxicol Pharmacol 2008; 25: 192-196.
26. Mennicken F, Maki R, de Souza EB, Quirion R. Chemokines and chemokine receptors in the CNS: a possible role in neuroinflammation and patterning. Trends Pharmacol Sci 1999; 20: 73-78.
27. Miao B, Yakubu S, Zhu Q, Issaka E, Zhang Y, Adams M. A review on tetrabromobisphenol A: Human biomonitoring, toxicity, detection and treatment in the environment. Molecules 2023; 28: 2505.
28. Mizuno T, Kawanokuchi J, Numata K, Suzumura A. Production and neuroprotective functions of fractalkine in the central nervous system. Brain Res 2003; 979: 65-70.
29. Reistad T, Mariussen E, Fonnum F. The effect of a brominated flame retardant, tetrabromobisphenol-A, on free radical formation in human neutrophil granulocytes: the involvement of the MAP kinase pathway and protein kinase C. Toxicol Sci 2005; 83: 89-100.
30. Ruan J, Guo J, Huang Y, Mao Y, Yang Z, Zuo Z. Adolescent exposure to environmental level of PCBs (Aroclor 1254) induces non-alcoholic fatty liver disease in male mice. Environ Res 2020; 181: 108909.
31. Starner TD, Barker CK, Jia HP, Kang Y, McCray PB Jr. CCL20 is an inducible product of human airway epithelia with innate immune properties. Am J Respir Cell Mol Biol 2003; 29: 627-633.
32. Strużyńska L, Dabrowska-Bouta B, Koza K, Sulkowski G. Inflammation-like glial response in lead-exposed immature rat brain. Toxicol Sci 2007; 95: 156-162.
33. Strużyńska L, Sulkowski G, Dąbrowska-Bouta B. Aroclor 1254 selectively inhibits expression of glial GLT-1 glutamate transporter in the forebrain of chronically exposed adult rat. Toxicology 2012; 300: 12-18.
34. Takano K, Nakagawa H. Contribution of cytokine-induced neutrophil chemoattractant CINC-2 and CINC-3 to neutrophil recruitment in lipopolysaccharide-induced inflammation in rats. Inflamm Res 2001; 50: 503-508.
35. Thomsen C, Lundanes E, Becher G. Brominated flame retardants in plasma samples from three different occupational groups in Norway. J Environ Monit 2001; 3: 366-370.
36. Tisoncik JR, Korth MJ, Simmons CP, Farrar J, Martin TR, Katze MG. Into the eye of the cytokine storm. Microbiol Mol Biol Rev 2012; 76: 16-32.
37. Tzeng SF, Hsiao HY, Mak OT. Prostaglandins and cyclooxygenases in glial cells during brain inflammation. Curr Drug Targets Inflamm Allergy 2005; 4: 335-40.
38. Watanabe W, Shimizu T, Sawamura R, Hino A, Konno K, Hirose A, Kurokawa M. Effects of tetrabromobisphenol A, a brominated flame retardant, on the immune response to respiratory syncytial virus infection in mice. Int Immunopharmacol 2010; 10: 393-397.
39. Weijs L, Covaci A, Yang RS, Das K, Blust R. Computational toxicology: Physiologically based pharmacokinetic models (PBPK) for lifetime exposure and bioaccumulation of polybrominated diphenyl ethers (PBDEs) in marine mammals. Environ Pollut 2012; 163: 134-141.
40. Wells TN, Power CA, Proudfoot AE. Definition, function and pathophysiological significance of chemokine receptors. Trends Pharmacol Sci 1998; 19: 376-380.
41. Xu S, Sun X, Wu J, Li K, Li X, Zhang Y, Gao XJ. TBBPA causes inflammation and cell death via the ROS/NF-κB pathway in the gastric mucosa. Ecotoxicol Environ Saf 2023; 262: 115320.
42. Yang R, Wei H, Guo J, Li A. Emerging brominated flame retardants in the sediment of the Great Lakes. Environ Sci Technol 2012; 46: 3119-3126.
43. Yermakova A, O’Banion MK. Cyclooxygenases in the central nervous system: implications for treatment of neurological disorders. Curr Pharm Des 2000; 6: 1755-1776.
44. Zhang D, Hu X, Qian L, O’Callaghan JP, Hong JS. Astrogliosis in CNS pathologies: is there a role for microglia? Mol Neurobiol 2010; 41: 232-241.
45. Zhang W, Xiao D, Mao Q, Xia H. Role of neuroinflammation in neurodegeneration development. Signal Transduct Target Ther 2023; 8: 267.
46. Zhang Y, Xu S, Li K, Li X, Yin H, Li S, Gao XJ. TBBPA induced ROS overproduction promotes apoptosis and inflammation by inhibiting autophagy in mice lung. Ecotoxicol Environ Saf 2023; 252: 114607.
47. Zhu DH, Nie FH, Zhang M, Wei W, Song QL, Hu Y, Kang DJ, Chen ZB, Lin HY, Chen JJ. Effects of Aroclor 1254 on intestinal immunity, metabolism, and microflora in zebrafish. Front Nutr 2022; 9: 929925.
48. Ziebell JM, Morganti-Kossmann MC. Involvement of pro- and anti-inflammatory cytokines and chemokines in the pathophysiology of traumatic brain injury. Neurotherapeutics 2010; 7: 22-30.
49. Zujovic V, Benavides J, Vigé X, Carter C, Taupin V. Fractalkine modulates TNF-alpha secretion and neurotoxicity induced by microglial activation. Glia 2000; 29: 305-310.
Copyright: © 2024 Mossakowski Medical Research Centre Polish Academy of Sciences and the Polish Association of Neuropathologists. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
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