The evaluation of the effectiveness of RESAN vaccine in the prophylaxis and the treatment of endometriosis  – an experimental study with an animal model. Part III – Is the histological confirmation of diagnosis necessary?

Krzysztof Szymanowski; Karolina Chmaj-Wierzchowska; Joanna Niepsuj; Andrey Yanchanka; Ewa Florek; Magdalena Barlik; Tomasz Opala

eISSN: 2299-0038
ISSN: 1643-8876

Menopause Review/Przegląd Menopauzalny

Current issue Archive Manuscripts accepted About the journal Special Issues Editorial board Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures

Editorial System

Submit your Manuscript

Editorial Policies

Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

Open access

1/2008
vol. 7

Send email

Copy url:

abstract:

The evaluation of the effectiveness of RESAN vaccine in the prophylaxis and the treatment of endometriosis – an experimental study with an animal model. Part III – Is the histological confirmation of diagnosis necessary?

Krzysztof Szymanowski

,

Karolina Chmaj-Wierzchowska

,

Joanna Niepsuj

,

Andrey Yanchanka

,

Ewa Florek

,

Magdalena Barlik

,

Tomasz Opala

Przegląd Menopauzalny 2008; 1: 23–28

Online publish date: 2008/03/03

View full text Get citation

EndNote

Papers, Reference Manager, RefWorks, Zotero

AMA

Szymanowski K, Chmaj-Wierzchowska K, Niepsuj J, et al. The evaluation of the effectiveness of RESAN vaccine in the prophylaxis and the treatment of endometriosis  – an experimental study with an animal model. Part III – Is the histological confirmation of diagnosis necessary?. Menopause Review/Przegląd Menopauzalny. 2008;7(1):23-28.

APA

Szymanowski, K., Chmaj-Wierzchowska, K., Niepsuj, J., Yanchanka, A., Florek, E.,  & Barlik, M. et al. (2008). The evaluation of the effectiveness of RESAN vaccine in the prophylaxis and the treatment of endometriosis  – an experimental study with an animal model. Part III – Is the histological confirmation of diagnosis necessary?. Menopause Review/Przegląd Menopauzalny, 7(1), 23-28.

Chicago

Szymanowski, Krzysztof, Karolina Chmaj-Wierzchowska, Joanna Niepsuj, Andrey Yanchanka, Ewa Florek, Magdalena Barlik,  and Tomasz Opala. 2008. "The evaluation of the effectiveness of RESAN vaccine in the prophylaxis and the treatment of endometriosis  – an experimental study with an animal model. Part III – Is the histological confirmation of diagnosis necessary?". Menopause Review/Przegląd Menopauzalny 7 (1): 23-28.

Harvard

Szymanowski, K., Chmaj-Wierzchowska, K., Niepsuj, J., Yanchanka, A., Florek, E., Barlik, M.,  and Opala, T. (2008). The evaluation of the effectiveness of RESAN vaccine in the prophylaxis and the treatment of endometriosis  – an experimental study with an animal model. Part III – Is the histological confirmation of diagnosis necessary?. Menopause Review/Przegląd Menopauzalny, 7(1), pp.23-28.

MLA

Szymanowski, Krzysztof et al. "The evaluation of the effectiveness of RESAN vaccine in the prophylaxis and the treatment of endometriosis  – an experimental study with an animal model. Part III – Is the histological confirmation of diagnosis necessary?." Menopause Review/Przegląd Menopauzalny, vol. 7, no. 1, 2008, pp. 23-28.

Vancouver

Szymanowski K, Chmaj-Wierzchowska K, Niepsuj J, Yanchanka A, Florek E, Barlik M et al. The evaluation of the effectiveness of RESAN vaccine in the prophylaxis and the treatment of endometriosis  – an experimental study with an animal model. Part III – Is the histological confirmation of diagnosis necessary?. Menopause Review/Przegląd Menopauzalny. 2008;7(1):23-28.

Introduction: According to ESHRE guidelines each case of deep and infiltrating endometriosis or endometriosis with endometrial cysts needs to be histopathologically diagnosed. Objective: The aim of this study was to compare preliminary and conclusive diagnoses of endometriosis during experimental study with an animal model. Material and methods: A group of 58 sexually mature female rats was divided into three smaller groups. During the first step of the experiment RESAN vaccine was injected among rats of group I (n=24). Three months later during the 2nd step of examination endometriosis was implanted in groups I and II (n=24). Group III (n=10) was a control group where sham operations were performed. Three months later, endometrial implants were removed and examined histologically. Meanwhile RESAN vaccine was injected as a treatment in group II (step 3). Three months later an excision of the suspected foci was performed with histological examination of the tissue samples (step 4). Cysts and/or adhesions surrounding the implant and/or congestion foci were treated as endometriosis markers. Results: In group I endometriosis was macroscopically diagnosed in 5 cases, but histologically confirmed just in 1 rat. During the 4th step there were no endometriosis markers in group I. During the 2nd step of the experiment endometriosis was suspected in 21 rats and confirmed in 16 cases. Three months later, 12 among 16 rats with endometriosis did not have any signs of that disease in preliminary and conclusive examination. Conclusions: Every macroscopic diagnosis of endometriosis needs to be confirmed with histological examination.

keywords:

The evaluation of the effectiveness of RESAN vaccine in the prophylaxis and the treatment of endometriosis – an experimental study with an animal model. Part III – Is the histological confirmation of diagnosis necessary?

Krzysztof Szymanowski , Karolina Chmaj-Wierzchowska , Joanna Niepsuj , Andrey Yanchanka , Ewa Florek , Magdalena Barlik , Tomasz Opala

endometriosis, RESAN, vaccine, immunoprophylaxis, immunotherapy, rat

Krzysztof Szymanowski

,

Karolina Chmaj-Wierzchowska

,

Joanna Niepsuj

,

Andrey Yanchanka

,

Ewa Florek

,

Magdalena Barlik

,

Tomasz Opala