eISSN: 1897-4309
ISSN: 1428-2526
Contemporary Oncology/Współczesna Onkologia
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SCImago Journal & Country Rank
3/2021
vol. 25
 
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abstract:
Original paper

The impact of G protein-coupled oestrogen receptor 1 on male breast cancer: a retrospective analysis

Jan-Hendrik Maiwald
1
,
Susanne Sprung
2
,
Piotr Czapiewski
1, 3
,
Wiebke Lessel
1
,
Anna Scherping
1
,
Dirk Schomburg
4
,
Markus Plaumann
4
,
Bartłomiej Tomasik
5, 6
,
Gerhard Behre
7
,
Johannes Haybaeck
1, 2, 8, 9
,
Atanas Ignatov
10
,
Holm Eggemann
11
,
Norbert Nass
1, 7

  1. Department of Pathology, Otto von Guericke University Magdeburg, Magdeburg, Germany
  2. Institute of Pathology, Neuropathology and Molecular Pathology, Medical University of Innsbruck, Innsbruck, Austria
  3. Department of Pathology, Dessau Medical Centre, Dessau, Germany
  4. Institute for Biometrics and Medical Informatics, Otto von Guericke University Magdeburg, Magdeburg, Germany
  5. Department of Biostatistics and Translational Medicine, Medical University of Lodz, Lodz, Poland
  6. Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA, USA
  7. Clinic for Internal Medicine I, Dessau Medical Centre, Dessau, Germany
  8. Diagnostic & Research Centre for Molecular Biomedicine, Institute of Pathology, Medical University of Graz, Graz, Austria
  9. Center for Biomarker Research in Medicine, Graz, Austria
  10. Department of Obstetrics and Gynaecology, Otto von Guericke University Magdeburg, Magdeburg, Germany
  11. Department of Obstetrics and Gynaecology, Hospital Magdeburg GmbH, Magdeburg, Germany
Contemp Oncol (Pozn) 2021; 25 (3): 204–212
Online publish date: 2021/10/14
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Introduction
The G protein-coupled oestrogen receptor 1 (GPER-1) is a potential prognostic marker in breast cancer. However, its role in male breast cancer (MBC) is still unknown. This study evaluates the expression of GPER-1 in MBC samples and correlates these data with clinical and pathological parameters including patients’ survival.

Material and methods
For this retrospective analysis of a prospectively maintained cohort of patients with MBC, we examined 161 specimens for GPER-1 expression using immunohistochemistry. An immunoreactive score (IRS) was calculated based on staining intensity and the percentage of positive tumour cells. Then, we correlated GPER-1 IRS with clinical and pathological parameters, and overall and relapse-free survival.

Results
About 40% of MBC samples were positive for GPER-1 expression (IRS ≥ 4). There was no significant correlation with clinicopathological parameters, such as hormone receptor status or grading. However, a statistical trend was observed for tumour size (≥ 2 cm, p = 0.093). Kaplan-Meier survival analysis revealed no significant correlation with relapse-free survival. However, there was a significant correlation with overall survival, but when we adjusted the log-rank p-value to compensate for the cut-off point optimization method, it rose above 0.1. Additionally, GPER-1-positive patients were older at diagnosis. When adjusted for age by multivariable Cox regression analysis, the significance of GPER-1 status for survival was further reduced.

Conclusions
We found no significant prognostic value of GPER-1 in this MBC cohort as anticipated from studies on female BC. Future studies with higher sample size are needed to further verify a potential sex-specific role of GPER-1.

keywords:

male breast cancer, MBC, survival analysis, GPER-1, GPR30, OS, RFS

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