–2518 A/G MCP-1 but not –403 G/A RANTES gene polymorphism is associated with enhanced risk
of basal cell carcinoma

Michał Sobjanek; Monika Zabłotna; Aneta Szczerkowska-Dobosz; Katarzyna Ruckemann-Dziurdzińska; Malgorzata Sokolowska-Wojdylo; Roman Nowicki

doi:10.5114/ada.2016.62846

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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abstract:

Original paper

–2518 A/G MCP-1 but not –403 G/A RANTES gene polymorphism is associated with enhanced risk of basal cell carcinoma

Michał Sobjanek

,

Monika Zabłotna

,

Aneta Szczerkowska-Dobosz

,

Katarzyna Ruckemann-Dziurdzińska

,

Malgorzata Sokolowska-Wojdylo

,

Roman Nowicki

Adv Dermatol Allergol 2016; XXXIII (5): 381-385

DOI: https://doi.org/10.5114/ada.2016.62846

Online publish date: 2016/10/21

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AMA

Sobjanek M, Zabłotna M, Szczerkowska-Dobosz A, Ruckemann-Dziurdzińska K, Sokolowska-Wojdylo M, Nowicki R. –2518 A/G MCP-1 but not –403 G/A RANTES gene polymorphism is associated with enhanced risk
of basal cell carcinoma. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2016;33(5):381-385. doi:10.5114/ada.2016.62846.

APA

Sobjanek, M., Zabłotna, M., Szczerkowska-Dobosz, A., Ruckemann-Dziurdzińska, K., Sokolowska-Wojdylo, M.,  & Nowicki, R. (2016). –2518 A/G MCP-1 but not –403 G/A RANTES gene polymorphism is associated with enhanced risk
of basal cell carcinoma. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 33(5), 381-385. https://doi.org/10.5114/ada.2016.62846

Chicago

Sobjanek, Michał, Monika Zabłotna, Aneta Szczerkowska-Dobosz, Katarzyna Ruckemann-Dziurdzińska, Malgorzata Sokolowska-Wojdylo,  and Roman Nowicki. 2016. "–2518 A/G MCP-1 but not –403 G/A RANTES gene polymorphism is associated with enhanced risk
of basal cell carcinoma". Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii 33 (5): 381-385. doi:10.5114/ada.2016.62846.

Harvard

Sobjanek, M., Zabłotna, M., Szczerkowska-Dobosz, A., Ruckemann-Dziurdzińska, K., Sokolowska-Wojdylo, M.,  and Nowicki, R. (2016). –2518 A/G MCP-1 but not –403 G/A RANTES gene polymorphism is associated with enhanced risk
of basal cell carcinoma. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 33(5), pp.381-385. https://doi.org/10.5114/ada.2016.62846

MLA

Sobjanek, Michał et al. "–2518 A/G MCP-1 but not –403 G/A RANTES gene polymorphism is associated with enhanced risk
of basal cell carcinoma." Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, vol. 33, no. 5, 2016, pp. 381-385. doi:10.5114/ada.2016.62846.

Vancouver

Sobjanek M, Zabłotna M, Szczerkowska-Dobosz A, Ruckemann-Dziurdzińska K, Sokolowska-Wojdylo M, Nowicki R. –2518 A/G MCP-1 but not –403 G/A RANTES gene polymorphism is associated with enhanced risk
of basal cell carcinoma. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2016;33(5):381-385. doi:10.5114/ada.2016.62846.

Introduction: Polymorphic variants of MCP-1 and RANTES genes and their protein serum levels have been implicated in the increased risk and severity of several malignancies. However, the subject has not been explored in basal cell carcinoma (BCC) patients so far.

Aim: To investigate the association between monocyte chemoattractant protein 1 (MCP-1) (–2518 A/G) and RANTES (–403 G/A) polymorphism and risk and clinical course of BCC.

Material and methods: The study group consisted of 150 unrelated patients with BCC and 140 healthy, unrelated, age- and sex-matched volunteers. The polymorphisms were analysed using the amplification refractory mutation system polymerase chain reaction method (ARMS-PCR) and single specific primer-polymerase chain reaction (SSP-PCR). Serum cytokine levels were measured with ELISA.

Results: The presence of the MCP-1 –2518 GG genotype was statistically more frequent in BCC patients and it increased the risk of BCC (OR = 2.63, p = 0.003). Genotype –330 GG was statistically more common in patients with less advanced tumours (OR = 2.8, p = 0.017). Monocyte chemoattractant protein 1 serum level was statistically higher with GG genotype. In the BCC group MCP-1 serum levels were decreased. Neither polymorphic variants of RANTES nor the chemokine serum concentration differed significantly between the study groups.

Conclusions: These findings suggest that –2518 A/G MCP-1 polymorphism may be involved in BCC pathogenesis.

keywords:

monocyte chemo-attractant protein 1, monocyte chemoattractant protein 1, CCL2, regulated upon activation normal T-cell expressed and secreted, RANTES, CCL5, gene polymorphism, basal cell carcinoma, BCC

–2518 A/G MCP-1 but not –403 G/A RANTES gene polymorphism is associated with enhanced risk of basal cell carcinoma

Michał Sobjanek , Monika Zabłotna , Aneta Szczerkowska-Dobosz , Katarzyna Ruckemann-Dziurdzińska , Malgorzata Sokolowska-Wojdylo , Roman Nowicki

monocyte chemo-attractant protein 1, monocyte chemoattractant protein 1, CCL2, regulated upon activation normal T-cell expressed and secreted, RANTES, CCL5, gene polymorphism, basal cell carcinoma, BCC

Michał Sobjanek

,

Monika Zabłotna

,

Aneta Szczerkowska-Dobosz

,

Katarzyna Ruckemann-Dziurdzińska

,

Malgorzata Sokolowska-Wojdylo

,

Roman Nowicki