-2518A/G polymorphism of monocyte chemotactic protein 1 (MCP-1/CCL2) is associated with cutaneous
mastocytosis

Hanna Ługowska-Umer; Monika Zabłotna; Magdalena Lange; Marek Niedoszytko; Roman Nowicki; Boguslaw Nedoszytko

doi:10.5114/ada.2021.112277

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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abstract:

Original paper

-2518A/G polymorphism of monocyte chemotactic protein 1 (MCP-1/CCL2) is associated with cutaneous mastocytosis

Hanna Ługowska-Umer

¹

,

Monika Zabłotna

¹

,

Magdalena Lange

¹

,

Marek Niedoszytko

²

,

Roman J. Nowicki

¹

,

Boguslaw Nedoszytko

¹

Department of Dermatology, Venereology and Allergology, Medical University of Gdansk, Gdansk, Poland
Department of Allergology, Medical University of Gdansk, Gdansk, Poland

Adv Dermatol Allergol 2021; XXXVIII (6): 1039-1043

DOI: https://doi.org/10.5114/ada.2021.112277

Online publish date: 2022/01/07

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AMA

Ługowska-Umer H, Zabłotna M, Lange M, Niedoszytko M, Nowicki RJ, Nedoszytko B. -2518A/G polymorphism of monocyte chemotactic protein 1 (MCP-1/CCL2) is associated with cutaneous
mastocytosis. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2021;38(6):1039-1043. doi:10.5114/ada.2021.112277.

APA

Ługowska-Umer, H., Zabłotna, M., Lange, M., Niedoszytko, M., Nowicki, R. J.,  & Nedoszytko, B. (2021). -2518A/G polymorphism of monocyte chemotactic protein 1 (MCP-1/CCL2) is associated with cutaneous
mastocytosis. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 38(6), 1039-1043. https://doi.org/10.5114/ada.2021.112277

Chicago

Ługowska-Umer, Hanna, Monika Zabłotna, Magdalena Lange, Marek Niedoszytko, Roman J Nowicki,  and Boguslaw Nedoszytko. 2021. "-2518A/G polymorphism of monocyte chemotactic protein 1 (MCP-1/CCL2) is associated with cutaneous
mastocytosis". Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii 38 (6): 1039-1043. doi:10.5114/ada.2021.112277.

Harvard

Ługowska-Umer, H., Zabłotna, M., Lange, M., Niedoszytko, M., Nowicki, R.,  and Nedoszytko, B. (2021). -2518A/G polymorphism of monocyte chemotactic protein 1 (MCP-1/CCL2) is associated with cutaneous
mastocytosis. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 38(6), pp.1039-1043. https://doi.org/10.5114/ada.2021.112277

MLA

Ługowska-Umer, Hanna et al. "-2518A/G polymorphism of monocyte chemotactic protein 1 (MCP-1/CCL2) is associated with cutaneous
mastocytosis." Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, vol. 38, no. 6, 2021, pp. 1039-1043. doi:10.5114/ada.2021.112277.

Vancouver

Ługowska-Umer H, Zabłotna M, Lange M, Niedoszytko M, Nowicki R, Nedoszytko B. -2518A/G polymorphism of monocyte chemotactic protein 1 (MCP-1/CCL2) is associated with cutaneous
mastocytosis. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2021;38(6):1039-1043. doi:10.5114/ada.2021.112277.

Introduction
Mastocytosis is a rare heterogeneous disease associated with pathological accumulation of mast cells (MCs) in one or more organs. The disease may be limited to the skin (cutaneous mastocytosis – CM), or present an internal organ involvement (systemic mastocytosis – SM). Pathophysiology of the disease is not well established. However altered proliferation, differentiation and chemotaxis of MC may play an essential role in the development of the disease. The monocyte chemotactic protein 1 (MCP-1/CCL2) may be one of the factors responsible for MCs migration to the skin and other organs.

Aim
To analyse the frequency of biallelic A/G polymorphisms at position -2518 in the promoter of the MCP-1 gene and compare the serum level of MCP-1 in patients with both forms of mastocytosis and the healthy control group.

Material and methods
Using ARMS-PCR methods we analysed -2518A/G polymorphisms in the promoter region of the MCP-1 gene in 127 mastocytosis patients (95 CM and 32 SM), and 160 healthy controls. Additionally, the MCP-1 serum level was detected with ELISA technique in 70 patients and 40 controls.

Results
We have found that CM patients have more frequently the GG genotype of the MCP-1 gene (p = 0.01) in comparison to SM patients and controls. The GG genotype was more frequent in children than in adults (p = 0.02). The MCP-1 serum level was higher in SM patients than in CM patients and controls.

Conclusions
Results of this study indicate that cutaneous mastocytosis could be associated with the -2518 A/G MPC-1 gene polymorphism.

keywords:

-2518A/G polymorphism of monocyte chemotactic protein 1 (MCP-1/CCL2) is associated with cutaneous mastocytosis

Hanna Ługowska-Umer 1 , Monika Zabłotna 1 , Magdalena Lange 1 , Marek Niedoszytko 2 , Roman J. Nowicki 1 , Boguslaw Nedoszytko 1

MCP-1 gene polymorphism, systemic mastocytosis, cutaneous mastocytosis

Hanna Ługowska-Umer

¹

,

Monika Zabłotna

¹

,

Magdalena Lange

¹

,

Marek Niedoszytko

²

,

Roman J. Nowicki

¹

,

Boguslaw Nedoszytko

¹