eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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4/2011
vol. 36
 
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abstract:

Clinical immunology
Fas+ lymphocytes and CD4+/CD25+ cells in peripheral blood of never smoking patients with chronic obstructive pulmonary disease

Joanna Domagała-Kulawik
,
Grażyna Hoser
,
Marta Dąbrowska
,
Renata Rubinsztain
,
Ryszarda Chazan

(Centr Eur J Immunol 2011; 36 (4): 226-232)
Online publish date: 2011/12/24
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The main causative agent for developing chronic obstructive pulmonary disease (COPD) is tobacco smoke. The important pathologic pathways in COPD which are related to smoking were well described. This disease affects mainly the respiratory tract. However, many data confirmed relevant systemic disturbances in course of COPD. Up to 30% of COPD cases are not attributable to smoking, however, little is known about the character of systemic inflammation in never smoking patients with COPD.

The objective of this study was the evaluation of main lymphocyte subtypes currently known to play a possible role in the pathogenesis of COPD in never smokers, and their comparison with smokers with COPD, asymptomatic smokers and healthy nonsmokers. Flow cytometry method with monoclonal antibodies was used for evaluation of lymphocyte subsets: T cells, B cells, T helper and T cytotoxic, T cells with regulatory properties and the expression of Fas (CD95) on T lymphocytes.

There were no differences in the proportion of T cells, B cells and CD4+ cells between the investigated groups. The proportion of CD8+ cells was significantly higher in patients with COPD than in healthy, both in non smokers and smokers group. The proportion of T lymphocytes with expression of Fas was significantly higher in never smoking patients with COPD and smokers with COPD when compared with asymptomatic smokers and nonsmokers (85% vs. 85.1% vs. 72.6% vs. 68.6% for CD4+/Fas+ and 83.2% vs. 89.1% vs. 74.3% vs. 58.8% for CD8+/Fas+ lymphocytes, respectively). The proportion of CD4+/CD25+ was lower in never smoking COPD patients than in never smoking healthy persons (14.2% vs. 19.2%).

Our observation indicates important disturbances in some lymphocyte subtypes not related to smoking and their possible role in systemic inflammation in COPD.
keywords:

never smokers, COPD, Fas, CD4+/CD25+ cells, lymphocytes
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