eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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1/2012
vol. 37
 
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abstract:

Clinical immunology
Impact of immunoglobulin G3 subclass deficiency on chronic lung disease in children

Aleksandra Szczawińska-Popłonyk
,
Anna Bręborowicz
,
Lidia Ossowska

(Centr Eur J Immunol 2012; 37 (1): 30-35)
Online publish date: 2012/03/29
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In this paper molecular and functional characteristics of immunoglobulin G3 (IgG3) subclass are described as well as clinical relevance of IgG3 deficiency in children with a review of the current literature. Special emphasis is put on the impact of this immune defect on chronic lung disease as presented with examples of pediatric patients. Finally, indications for treatment in IgG3 deficient children and therapeutic options are discussed.
keywords:

immunodeficiency, IgG subclass, lungs, infection, children
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