eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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4/2007
vol. 32
 
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abstract:


Clinical immunology
NF-κB expression in mononuclear cells from patients with chronic heart failure observed in endotoxin tolerance

Ewa Zaczyńska
,
Anna Czarny
,
Ewa A. Jankowska
,
Maciej Sobczyński
,
Piotr Ponikowski

(Centr Eur J Immunol 2007; 32 (4): 206-211)
Online publish date: 2007/12/10
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Inflammatory immune activation is observed in patients with chronic heart failure (CHF). LPS translocated from the intestine into circulation during episodes of decompensation can modulate the activation of immunocompetent cells in patients with CHF.
The expression of transcriptional nuclear factor kappa-B (NF-κB) in patients with CHF was significantly highest than control subject. Subsequently in vitro stimulation of peripheral blood mononuclear cells (PBMC) with lipopolysaccharide (LPS) did not induce NF-κB nuclear translocation in cells from patients with CHF with NYHA II-IV as compared to the cells from healthy patients with LPS induction. This phenomenon of “LPS- tolerance” or “deactivation” can explain the endotoxin hypothesis, which suggests that bacterial translocation through the oedematous gut wall with subsequent release of endotoxin may pose the relevant stimulus to trigger NF-κB system.
keywords:

nuclear factor kappa-B, chronic heart failure, LPS, peripheral mononuclear cells
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