eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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1/2012
vol. 37
 
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abstract:

Experimental immunology
Effects of gossypol acetic acid on cellular and humoral immune response in non-immunized and SRBC-immunized mice

Deng Sijun
,
Aleksandra Pawlak
,
Błażej Poźniak
,
Agnieszka Suszko
,
Marianna Szczypka
,
Yuan Hui
,
Bożena Obmińska-Mrukowicz

(Centr Eur J Immunol 2012; 37 (1): 11-19)
Online publish date: 2012/03/29
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Gossypol is a yellow polyphenolic compound from cotton plant. It has been shown to exert a potential for anti-cancer, anti-inflammatory and anti-fertility effects. Following effects of gossypol acetic acid (GA) in mice were determined in the present study: influence on the total number of lymphocytes, weight ratio and subsets of lymphocytes in the thymus, spleen and mesenteric lymph nodes, and humoral immune response to sheep erythrocytes (SRBC). Gossypol acetic acid was administered orally four times at 24 h intervals at three doses of 5.0, 25.0 and 125.0 mg/kg to SRBC-immunized mice (prior to or after priming), and non-immunized mice. It was found that GA decreased the total number of lymphocytes in thymus and mesenteric lymph nodes. Gossypol acetic acid dependent on the dosage decreased the percentage and absolute count of CD4+ thymocytes but increased the percentage and absolute count of CD8+ lymphocytes in spleen and lymph nodes. In SRBC-immunized mice, GA at the doses of 25.0 and

125.0 mg/kg administered prior to SRBC reduced the number of plaque forming cells (PFC) and the production of IgG. However, GA administered after priming decreased the production of IgM and IgG.

In vitro, GA inhibited proliferation of J774.E murine macrophages in a dose- and time-dependent manner.
keywords:

gossypol acetic acid, cellular response, humoral response, lymphatic organs, mice
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