eISSN: 1644-4124
ISSN: 1426-3912
Central European Journal of Immunology
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2/2012
vol. 37
 
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abstract:

Experimental immunology
The effect of Rhodiola kirilowii extracts on tumor-induced angiogenesis in mice

Robert Zdanowski
,
Ewa Skopińska-Różewska
,
Aleksander Wasiutyński
,
Piotr Skopiński
,
Andrzej K. Siwicki
,
Elżbieta Sobiczewska
,
Sławomir Lewicki
,
Waldemar Buchwald
,
Janusz Kocik
,
Wanda Stankiewicz

(Centr Eur J Immunol 2012; 37 (2): 131-139)
Online publish date: 2012/05/22
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Rhodiola kirilowii is an adaptogenic plant indigenous to the high altitude of Qinghai-Tibet Plateau in China. The plant is used in the Chinese traditional medicine for various purposes, mainly as general adaptogen for enhancement of the ability of anti-anoxia, protecting people against cardiopulmonary function problems when moving to high altitude, mild anti-stress and anti-inflammatory action. In our previous studies we obtained for the first time evidence of in vitro and in vivo immunotropic activity of Rhodiola kirilowii aqueous (RKW) and hydro-alcoholic (RKA) extracts in mice, rats and pigs. The first aim of the present work was to compare the in vivo influence of these two extracts on cutaneous angiogenesis induced in Balb/c mice by grafting sarcoma L-1 syngeneic tumor cells. The second aim was to compare the in vitro influence of RKW and RKA extracts on the migration as well as on the proliferation of murine endothelial (HECa10) cells and on the proliferation of murine tumor (L-1 sarcoma) cells in tissue culture.

Results: In vivo, RKA administered orally significantly suppressed neovascular reaction to L-1 sarcoma cells. Rhodiola kirilowii aqueous had no influence on cutaneous angiogenesis reaction. In vitro, experiments showed that both extracts have stimulated the proliferation of HECa10 cells, and both of them suppressed proliferation of L-1 sarcoma cells. Inhibitory effect of RKA extract and stimulatory influence of RKW extract on HECa10 cells migration in the presence of L-1 sarcoma cells were observed. These findings might partly explain the differences in their in vivo effect.
keywords:

angiogenesis, mice, HECa10, migration, proliferation, L-1 sarcoma, Rhodiola kirilowii
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