eISSN: 1897-4317
ISSN: 1895-5770
Gastroenterology Review/Przegląd Gastroenterologiczny
Current issue Archive Manuscripts accepted About the journal Editorial board Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
Search
Editorial Policies
Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

Open access

without publication fees
2/2014
vol. 9
 
Share:
Send email
Share:
abstract:
Original paper

IRS-2 G1057D polymorphism in Turkish patients with colorectal cancer

Emel Hulya Yukseloglu
,
Sevim Karakas Celik
,
Meral Urhan Kucuk
,
Erdinc Yalin
,
S. Sebnem Ozkal
,
Cengiz Ates
,
Mehmet Berkoz
,
Serap Yalin
,
Nurcan Aras Ates

Prz Gastroenterol 2014; 9 (2): 88–92
DOI: https://doi.org/10.5114/pg.2014.42503
Online publish date: 2014/05/05
View full text Get citation
 
PlumX metrics:
Introduction: Gene polymorphisms have a broad range of analysis, but are of particular use in molecular medicine due to their potential in revealing the genetic tendency in diseases such as cancer, heart attack etc. These studies basically depend on mutations that can be detected by proper techniques. The genes coding the insulin receptor substrate (IRS) proteins are among the most widely analysed polymorphisms in various cancer types, in which a G1057D mutation is seen.

Aim: To determine the risk of colon cancer by analysing the IRS-2 gene polymorphism in Turkish patients.

Material and methods: A total of 161 newly diagnosed colorectal cancer patients were analysed and compared to 197 unrelated healthy controls. A polymerase chain reaction-based restriction fragment length polymorphism method was carried out.

Results: No differences were observed between the patient and control groups for both allele and genotype frequencies of the IRS-2 G1057D gene.

Conclusions: Our results demonstrated that IRS-2 G1057D polymorphism is not associated with colorectal cancer in the Turkish population. This research is a preliminary and original study in Turkish patients with colorectal cancer. It also provides population-level genetic data on IRS-2 in the Turkish population. Further studies should be performed on larger number of patients and controls for more reliable results about the genetic tendency in colorectal cancer in Turkey. The study is a collaborative work of different universities and scientists.
keywords:

IRS-2, colon cancer, polymorphism, Turkey
Termedia
About us Contact
Copyright notice Privacy policy Advertising policy Contact us
Quick links
Journals Books eBooks Events
© 2024 Termedia Sp. z o.o.
Developed by Bentus.