Review paper Natural TH2 (nTH2) cells, interleukin 36 and interleukin 37 – new elements of innate immunity

Agata Mękal; Alicja Trzeciak-Ryczek; Beata Tokarz-Deptuła; Wiesław Deptuła

eISSN: 1644-4124
ISSN: 1426-3912

Central European Journal of Immunology

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2/2011
vol. 36

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abstract:

Review paper
Natural T_H2 (nT_H2) cells, interleukin 36 and interleukin 37 – new elements of innate immunity

Agata Mękal

,

Alicja Trzeciak-Ryczek

,

Beata Tokarz-Deptuła

,

Wiesław Deptuła

(Centr Eur J Immunol 2011; 36 (2): 113-116)

Online publish date: 2011/06/20

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This paper presents new elements of innate immunity, such as recently described natural T_H2 cells (nT_H2 or NHC), interleukin 36 (IL-36) and IL-37. nT_H2 cells are located in structures defined as fat-associated lymphoid clusters (FALC), and their role is principally associated with the production of cytokines that are characteristic for T_H2 lymphocytes participating in the course of allergic processes and in host defence during invasions of various parasites. The expression of IL-36 was mainly recorded in the thymus, testis and uterus cells. This interleukin indicates suppressive effect on innate immunity, principally by inhibition of pro-inflammatory cytokine production, as well as by creation of an active complex with signalling protein – Smad3 and cooperation with TGF-β. In turn, IL-37 is synthesized in the same places as IL-36, and additionally in macrophages and epithelial cells. It is also considered as an inhibitor of innate immunity.

keywords:

Review paperNatural TH2 (nTH2) cells, interleukin 36 and interleukin 37 – new elements of innate immunity

Agata Mękal , Alicja Trzeciak-Ryczek , Beata Tokarz-Deptuła , Wiesław Deptuła

innate immunity, nTH2 cells, IL-36, IL-37

Review paper
Natural T_H2 (nT_H2) cells, interleukin 36 and interleukin 37 – new elements of innate immunity

Agata Mękal

,

Alicja Trzeciak-Ryczek

,

Beata Tokarz-Deptuła

,

Wiesław Deptuła

innate immunity, nT_H2 cells, IL-36, IL-37