eISSN: 2084-9869
ISSN: 1233-9687
Polish Journal of Pathology
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1/2011
vol. 62
 
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abstract:

A case of prostatic adenocarcinoma with Paneth cell-like appearance

Yasuhiro Nakamura
,
Fumiyoshi Fujishima
,
Mika Watanabe
,
Shinji Taniuchi
,
Kazuyuki Ishida
,
Shigeto Ishidoya
,
Yoichi Arai
,
Hironobu Sasano

Pol J Pathol 2011; 1: 60–64
Online publish date: 2011/05/11
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Paneth cell-like appearance of prostatic carcinoma cells with eosinophilic cytoplasmic granules is rarely reported, and is known to be associated with neuroendocrine differentiation of carcinoma cells. We report a case of prostatic adenocarcinoma with Paneth cell-like appearance that was localized next to conventional adenocarcinoma, and demonstrate its neuroendocrine differentiation by using immunohistochemical analysis. Paneth cell-like appearance of prostatic carcinoma cells should be recognized and considered as a sign of neuroendocrine differentiation due to the possible association with resistance to hormone therapy.
keywords:

prostatic adenocarcinoma, Paneth cell-like feature, neuroendocrine differentiation
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