A long-term responding epidermal growth factor receptor mutated non-small cell lung cancer patient with extremely high mutation allele frequency

Kunihiko Miyazaki; Yoshiharu Sato; Hiroaki Satoh; Nobuyuki Hizawa

doi:10.5114/wo.2022.115447

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

Current issue Archive Manuscripts accepted About the journal Supplements Addendum Special Issues Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures

Editorial System

Submit your Manuscript

Editorial Policies

Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

1/2022
vol. 26

Send email

Copy url:

abstract:

Letter to the Editor

A long-term responding epidermal growth factor receptor mutated non-small cell lung cancer patient with extremely high mutation allele frequency

Kunihiko Miyazaki

¹

,

Yoshiharu Sato

²

,

Hiroaki Satoh

³

,

Nobuyuki Hizawa

⁴

Ryugasaki Saiseikai Hospital, Japan
DNA Chip Research Inc., Tokyo, Japan
Mito Medical Center, University of Tsukuba, Japan
Faculty of Clinical Medicine, University of Tsukuba, Japan

Contemp Oncol (Pozn) 2022; 26 (1): 88–89

DOI: https://doi.org/10.5114/wo.2022.115447

Online publish date: 2022/03/30

View full text Get citation

PlumX metrics:

Epidermal growth factor receptor (EGFR) mutation is the most frequent oncogenic driver in non-small cell lung cancer (NSCLC) [1, 2]. Among EGFR mutations, exon 19 deletion and exon 21 L858R are two of the most common mutations; hence they are referred to as common mutations [1]. In addition to them, there are many types of EGFR mutation other than common mutations. They are treated as uncommon mutations [3, 4]. Recent advances in analysis technology using next-generation sequencing (NGS) have made great progress also in the area of EGFR mutation [5–8]. By this analytic method, it has become clear that there is heterogeneity among patients with common mutations. Among these possible heterogeneities, mutation allele frequency (MAF) has drawn attention [9–13]. MAF is defined as the number of times a mutated base is observed, divided by the total number of times any base is observed at the locus. It corresponds to the percentage of sequencing reads that contain the mutation, and the proportion of alleles is affected by the proportion of tumor cells in the sample and the presence of copy number alterations [9–13]. Here we report a case of a patient with EGFR mutation with very high MAF, who responded to EGFR-tyrosine kinases for a long time.

A long-term responding epidermal growth factor receptor mutated non-small cell lung cancer patient with extremely high mutation allele frequency

Kunihiko Miyazaki 1 , Yoshiharu Sato 2 , Hiroaki Satoh 3 , Nobuyuki Hizawa 4

Kunihiko Miyazaki

¹

,

Yoshiharu Sato

²

,

Hiroaki Satoh

³

,

Nobuyuki Hizawa

⁴