A rare CD5-positive subgroup of diffuse large B-cell lymphoma – clinical, morphological and immunophenotypic features in Polish patients

Nina Woźnialis; Beata Gierej; Lidia Popławska; Mateusz Ziarkiewicz; Elżbieta Kulczycka; Bogna Ziarkiewicz-Wróblewska

doi:10.5114/pjp.2016.63775

eISSN: 2084-9869
ISSN: 1233-9687

Polish Journal of Pathology

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abstract:

Original paper

A rare CD5-positive subgroup of diffuse large B-cell lymphoma – clinical, morphological and immunophenotypic features in Polish patients

Nina Woźnialis

¹

,

Beata Gierej

^{1, 2}

,

Lidia Popławska

³

,

Mateusz Ziarkiewicz

⁴

,

Elżbieta Kulczycka

¹

,

Bogna Ziarkiewicz-Wróblewska

^{1, 2}

Department of Pathology and Laboratory Diagnostics, Maria Skłodowska-Curie Institute and Oncology Centre, Warsaw, Poland
Department of Pathology, Center for Biostructure Research, Medical University of Warsaw, Warsaw, Poland
Department of Lymphoid Malignancies, Maria Skłodowska-Curie Institute and Oncology Centre, Warsaw, Poland
Department of Hematology, Oncology and Internal Medicine, Medical University of Warsaw, Warsaw, Poland

Pol J Pathol 2016; 67 (3): 235-243

DOI: https://doi.org/10.5114/pjp.2016.63775

Online publish date: 2016/11/25

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AMA

Woźnialis N, Gierej B, Popławska L, Ziarkiewicz M, Kulczycka E, Ziarkiewicz-Wróblewska B. A rare CD5-positive subgroup of diffuse large B-cell lymphoma – clinical, morphological and immunophenotypic features in Polish patients. Polish Journal of Pathology. 2016;67(3):235-243. doi:10.5114/pjp.2016.63775.

APA

Woźnialis, N., Gierej, B., Popławska, L., Ziarkiewicz, M., Kulczycka, E.,  & Ziarkiewicz-Wróblewska, B. (2016). A rare CD5-positive subgroup of diffuse large B-cell lymphoma – clinical, morphological and immunophenotypic features in Polish patients. Polish Journal of Pathology, 67(3), 235-243. https://doi.org/10.5114/pjp.2016.63775

Chicago

Woźnialis, Nina, Beata Gierej, Lidia Popławska, Mateusz Ziarkiewicz, Elżbieta Kulczycka,  and Bogna Ziarkiewicz-Wróblewska. 2016. "A rare CD5-positive subgroup of diffuse large B-cell lymphoma – clinical, morphological and immunophenotypic features in Polish patients". Polish Journal of Pathology 67 (3): 235-243. doi:10.5114/pjp.2016.63775.

Harvard

Woźnialis, N., Gierej, B., Popławska, L., Ziarkiewicz, M., Kulczycka, E.,  and Ziarkiewicz-Wróblewska, B. (2016). A rare CD5-positive subgroup of diffuse large B-cell lymphoma – clinical, morphological and immunophenotypic features in Polish patients. Polish Journal of Pathology, 67(3), pp.235-243. https://doi.org/10.5114/pjp.2016.63775

MLA

Woźnialis, Nina et al. "A rare CD5-positive subgroup of diffuse large B-cell lymphoma – clinical, morphological and immunophenotypic features in Polish patients." Polish Journal of Pathology, vol. 67, no. 3, 2016, pp. 235-243. doi:10.5114/pjp.2016.63775.

Vancouver

Woźnialis N, Gierej B, Popławska L, Ziarkiewicz M, Kulczycka E, Ziarkiewicz-Wróblewska B. A rare CD5-positive subgroup of diffuse large B-cell lymphoma – clinical, morphological and immunophenotypic features in Polish patients. Polish Journal of Pathology. 2016;67(3):235-243. doi:10.5114/pjp.2016.63775.

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The aim of the study was to assess the incidence of CD5-positive diffuse large B-cell lymphoma (DLBCL) in the Polish population and to describe its morphologic and clinical characteristics. The study included 36 patients with CD5-positive DLBCL, diagnosed and treated in the Maria Skłodowska-Curie Institute and Oncology Centre, Warsaw, Poland and the Medical University of Warsaw, Poland in the years 2002-2013. The control group consisted of 28 patients with CD5-negative DLBCL. CD5-positive DLBCL accounted for 6.26% of all DLBCL cases diagnosed in the Maria Skłodowska-Curie Institute and Oncology Centre in the years 2008-2012. The incidence is comparable to other European countries, lower than noted in Japan and higher than in the US. Patients with CD5-positive DLBCL, in comparison to the CD5-negative group, were characterized by: (1) older age (≥ 60 vs. younger) and worse general status (ECOG ≥ 2 vs. < 2), (2) lower frequency of complete remission (CR), (3) higher expression of unfavorable prognostic factors (BCL2, FOXP1, CD44) and MMP-9, and (4) lower expression of favorable prognostic factors (CD30, cyclin D1, cyclin D3) and TIMP-2.

keywords:

A rare CD5-positive subgroup of diffuse large B-cell lymphoma – clinical, morphological and immunophenotypic features in Polish patients

Nina Woźnialis 1 , Beata Gierej 1, 2 , Lidia Popławska 3 , Mateusz Ziarkiewicz 4 , Elżbieta Kulczycka 1 , Bogna Ziarkiewicz-Wróblewska 1, 2

NHL, CD5-positive DLBCL, prognostic factors

Nina Woźnialis

¹

,

Beata Gierej

^{1, 2}

,

Lidia Popławska

³

,

Mateusz Ziarkiewicz

⁴

,

Elżbieta Kulczycka

¹

,

Bogna Ziarkiewicz-Wróblewska

^{1, 2}