A retrospective evaluation of associations between chronic obstructive pulmonary disease, smoking, and efficacy of chemotherapy and selected laboratory parameters in patients with advanced non-small cell lung cancer

Rafał Czyżykowski; Dariusz Nowak; Anna Janiak; Anna Włodarczyk; Agata Sarniak; Magdalena Krakowska; Piotr Potemski

doi:10.5114/wo.2016.64605

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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5/2016
vol. 20

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abstract:

Original paper

A retrospective evaluation of associations between chronic obstructive pulmonary disease, smoking, and efficacy of chemotherapy and selected laboratory parameters in patients with advanced non-small cell lung cancer

Rafał Czyżykowski

,

Dariusz Nowak

,

Anna Janiak

,

Anna Włodarczyk

,

Agata Sarniak

,

Magdalena Krakowska

,

Piotr Potemski

Contemp Oncol (Pozn) 2016; 20 (5): 407-413

DOI: https://doi.org/10.5114/wo.2016.64605

Online publish date: 2016/12/20

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AMA

Czyżykowski R, Nowak D, Janiak A, et al. A retrospective evaluation of associations between chronic obstructive pulmonary disease, smoking, and efficacy of chemotherapy and selected laboratory parameters in patients with advanced non-small cell lung cancer. Contemporary Oncology/Współczesna Onkologia. 2016;20(5):407-413. doi:10.5114/wo.2016.64605.

APA

Czyżykowski, R., Nowak, D., Janiak, A., Włodarczyk, A., Sarniak, A.,  & Krakowska, M. et al. (2016). A retrospective evaluation of associations between chronic obstructive pulmonary disease, smoking, and efficacy of chemotherapy and selected laboratory parameters in patients with advanced non-small cell lung cancer. Contemporary Oncology/Współczesna Onkologia, 20(5), 407-413. https://doi.org/10.5114/wo.2016.64605

Chicago

Czyżykowski, Rafał, Dariusz Nowak, Anna Janiak, Anna Włodarczyk, Agata Sarniak, Magdalena Krakowska,  and Piotr Potemski. 2016. "A retrospective evaluation of associations between chronic obstructive pulmonary disease, smoking, and efficacy of chemotherapy and selected laboratory parameters in patients with advanced non-small cell lung cancer". Contemporary Oncology/Współczesna Onkologia 20 (5): 407-413. doi:10.5114/wo.2016.64605.

Harvard

Czyżykowski, R., Nowak, D., Janiak, A., Włodarczyk, A., Sarniak, A., Krakowska, M.,  and Potemski, P. (2016). A retrospective evaluation of associations between chronic obstructive pulmonary disease, smoking, and efficacy of chemotherapy and selected laboratory parameters in patients with advanced non-small cell lung cancer. Contemporary Oncology/Współczesna Onkologia, 20(5), pp.407-413. https://doi.org/10.5114/wo.2016.64605

MLA

Czyżykowski, Rafał et al. "A retrospective evaluation of associations between chronic obstructive pulmonary disease, smoking, and efficacy of chemotherapy and selected laboratory parameters in patients with advanced non-small cell lung cancer." Contemporary Oncology/Współczesna Onkologia, vol. 20, no. 5, 2016, pp. 407-413. doi:10.5114/wo.2016.64605.

Vancouver

Czyżykowski R, Nowak D, Janiak A, Włodarczyk A, Sarniak A, Krakowska M et al. A retrospective evaluation of associations between chronic obstructive pulmonary disease, smoking, and efficacy of chemotherapy and selected laboratory parameters in patients with advanced non-small cell lung cancer. Contemporary Oncology/Współczesna Onkologia. 2016;20(5):407-413. doi:10.5114/wo.2016.64605.

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Aim of the study: To was to determine the impact of chronic obstructive pulmonary disease (COPD) and active smoking on the efficacy of chemotherapy and complete blood count (CBC) in patients with non-small cell lung cancer (NSCLC).

Material and methods: The retrospective evaluation included 50 patients with stage IIIB–IV NSCLC, who started cisplatin-based chemotherapy. Peripheral blood CBC values were collected for testing before chemotherapy and after the first and third cycles.

Results: COPD was diagnosed in 49% of patients, while 42% of those enrolled were current smokers. Current smoking (p = 0.92) and COPD (p = 0.91) status did not affect the response to treatment. The non-COPD population presented a significantly higher pretreatment absolute lymphocyte count (ALC) than the COPD population (2.31 vs. 1.81 × 109/l; p = 0.0374). Also, only the non-COPD group demonstrated an elevated absolute monocyte count (AMC) following the first and third cycles of chemotherapy (p = 0.004). In current smokers, pretreatment values for white blood cells (WBC), absolute neutrophil count (ANC), and platelets (PLT) were higher than in the ex-smoker population (WBC 9.94 vs. 8.7 (× 109/l); p = 0.01; ANC 6.47 vs. 5.61 (× 109/l); p = 0.037; PLT 316 vs. 266 (× 109/l); p = 0.049). Ex-smokers demonstrated AMC level elevation after the first cycle of chemotherapy and PLT level elevation after the third cycle, while current smokers also demonstrated an early decrease in LMR. Conclusions: COPD and smoking induce chronic systemic inflammation and oxidative stress, which influence the results of standard laboratory tests, but do not change the response rate of lung cancer on chemotherapy.

keywords:

A retrospective evaluation of associations between chronic obstructive pulmonary disease, smoking, and efficacy of chemotherapy and selected laboratory parameters in patients with advanced non-small cell lung cancer

Rafał Czyżykowski , Dariusz Nowak , Anna Janiak , Anna Włodarczyk , Agata Sarniak , Magdalena Krakowska , Piotr Potemski

non-small cell lung cancer, chronic obstructive pulmonary disease, smoking, chemotherapy

Rafał Czyżykowski

,

Dariusz Nowak

,

Anna Janiak

,

Anna Włodarczyk

,

Agata Sarniak

,

Magdalena Krakowska

,

Piotr Potemski