A significance of genetic factor in initiation and progression of squamous cell carcinoma of larynx

Krzysztof Szyfter

eISSN: 2084-9842
ISSN: 1643-9279

Postępy w chirurgii głowy i szyi/Advances in Head and Neck Surgery

Current issue Archive About the journal Supplements Editorial board Abstracting and indexing Subscription Contact Instructions for authors Ethical standards and procedures

1/2002
vol. 1

Send email

Copy url:

abstract:

A significance of genetic factor in initiation and progression of squamous cell carcinoma of larynx

Krzysztof Szyfter

Post Chir Głowy i Szyi 2002; 1: 5-19

Online publish date: 2003/07/08

View full text Get citation

A significance of genetic factor in etiology of laryngeal cancer emerges when analysing a variable individual susceptibility to carcinogens. Genes coding enzymes taking part in carcinogenesis, divided on oncogenes, tumour suppressor genes and genes responsible for carcinogen metabolism are reviewed. The latter group is discussed in relation to their genetically determined polymorphic character responsible for an individually variable response to carcinogens present in tobacco smoke. A role of particular reviewed genes is discussed further in connection with a pattern of DNA lesions and chromosome aberrations.

keywords:

A significance of genetic factor in initiation and progression of squamous cell carcinoma of larynx

Krzysztof Szyfter

laryngeal cancer, genetic risk, genetic instability