A study on expression of programmed death ligand-1
in small cell lung carcinoma and correlation with
clinicopathological parameters

Sudha Sudha; Saumya Shukla; Nuzhat Husain; Hemant Kumar; Rahul Kumar Pandey; Surya Kant

doi:10.5114/pjp.2024.136281

eISSN: 2084-9869
ISSN: 1233-9687

Polish Journal of Pathology

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1/2024
vol. 75

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abstract:

Original paper

A study on expression of programmed death ligand-1 in small cell lung carcinoma and correlation with clinicopathological parameters

Sudha Sudha

¹

,

Saumya Shukla

¹

,

Nuzhat Husain

¹

,

Hemant Kumar

²

,

Rahul Kumar Pandey

¹

,

Surya Kant

³

Department of Pathology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow-UP, India
Department of Respiratory Medicine, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow-UP, India
Department of Respiratory Medicine, King George’s Medical University, Lucknow-UP, India

Pol J Pathol 2024; 75 (1): 25-35

DOI: https://doi.org/10.5114/pjp.2024.136281

Online publish date: 2024/03/15

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Small cell lung carcinoma (SCLC) is characterized by rapid growth and an aggressive clinical course. Standard therapy regimes have limited effects on disease course; therefore the prognosis of SCLC is poor. In the current study, the frequency of programmed death ligand 1 (PD-L1) expression in SCLC and its correlation with clinico-pathological features were evaluated.

The study included 100 cases of SCLC wherein testing for PD-L1 was done with the SP263 clone on the Ventana benchmark XT system. Cases with > 1% PD-L1 expression in tumour cells or immune cells were categorized as positive.

PD-L1 expression was identified in 14% of cases using the cut-off of ≥ 1%. The tumour proportion score was 10% and the immune proportion score was 9.78% using a cut-off of ≥ 1%. PD-L1 positive expression was more frequent in the male population with age > 40 years. All the patients with positive PD-L1 expression were smokers. In the PD-L1 positive group, presence of necrosis was identified in 71.4% of cases and when compared with the PD-L1 negative subgroup this finding was statistically significant (p = 0.010).

Personalized targeted therapy for cases of SCLC is still under evaluation. The use of immunotherapeutic targets, such as PD-L1, may help to define a new treatment strategy for SCLC. Development of new treatment strategies may improve prognosis and survival.

keywords:

A study on expression of programmed death ligand-1 in small cell lung carcinoma and correlation with clinicopathological parameters

Sudha Sudha 1 , Saumya Shukla 1 , Nuzhat Husain 1 , Hemant Kumar 2 , Rahul Kumar Pandey 1 , Surya Kant 3

immunotherapy, small cell lung carcinoma, programmed death ligand-1

Sudha Sudha

¹

,

Saumya Shukla

¹

,

Nuzhat Husain

¹

,

Hemant Kumar

²

,

Rahul Kumar Pandey

¹

,

Surya Kant

³