ANESTEZJOLOGIA I INTENSYWNA TERAPIA<br>Inhaled nitric oxide effects outside the lungs – proven and possible mechanisms

Waldemar Goździk; Anna Goździk

doi:10.5114/kitp.2012.30848

eISSN: 1897-4252
ISSN: 1731-5530

Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery

Current issue Archive Manuscripts accepted About the journal Supplements Editorial board Reviewers Abstracting and indexing Contact Instructions for authors Publication charge Ethical standards and procedures

Editorial System

Submit your Manuscript

3/2012
vol. 9

Send email

Copy url:

abstract:

ANESTEZJOLOGIA I INTENSYWNA TERAPIA
Inhaled nitric oxide effects outside the lungs – proven and possible mechanisms

Waldemar Goździk

,

Anna Goździk

Kardiochirurgia i Torakochirurgia Polska 2012; 3: 352–356

DOI: https://doi.org/10.5114/kitp.2012.30848

Online publish date: 2012/10/01

View full text Get citation

EndNote

Papers, Reference Manager, RefWorks, Zotero

AMA

Goździk W, Goździk A. ANESTEZJOLOGIA I INTENSYWNA TERAPIAInhaled nitric oxide effects outside the lungs – proven and possible mechanisms. Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery. 2012;9(3):352-356. doi:10.5114/kitp.2012.30848.

APA

Goździk, W.,  & Goździk, A. (2012). ANESTEZJOLOGIA I INTENSYWNA TERAPIAInhaled nitric oxide effects outside the lungs – proven and possible mechanisms. Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery, 9(3), 352-356. https://doi.org/10.5114/kitp.2012.30848

Chicago

Goździk, Waldemar,  and Anna Goździk. 2012. "ANESTEZJOLOGIA I INTENSYWNA TERAPIAInhaled nitric oxide effects outside the lungs – proven and possible mechanisms". Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery 9 (3): 352-356. doi:10.5114/kitp.2012.30848.

Harvard

Goździk, W.,  and Goździk, A. (2012). ANESTEZJOLOGIA I INTENSYWNA TERAPIAInhaled nitric oxide effects outside the lungs – proven and possible mechanisms. Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery, 9(3), pp.352-356. https://doi.org/10.5114/kitp.2012.30848

MLA

Goździk, Waldemar et al. "ANESTEZJOLOGIA I INTENSYWNA TERAPIAInhaled nitric oxide effects outside the lungs – proven and possible mechanisms." Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery, vol. 9, no. 3, 2012, pp. 352-356. doi:10.5114/kitp.2012.30848.

Vancouver

Goździk W, Goździk A. ANESTEZJOLOGIA I INTENSYWNA TERAPIAInhaled nitric oxide effects outside the lungs – proven and possible mechanisms. Kardiochirurgia i Torakochirurgia Polska/Polish Journal of Thoracic and Cardiovascular Surgery. 2012;9(3):352-356. doi:10.5114/kitp.2012.30848.

PlumX metrics:

Inhaled nitric oxide has been shown to reduce pulmonary hypertension in several disease states. The vasodilatory effect of inhaled nitric oxide is limited almost exclusively to the pulmonary circulation, due to its rapid diffusion across the capillary membrane and its immediate deactivation by hemoglobin in the pulmonary vasculature lumen. However, many reports on the use of inhaled nitric oxide have revealed a broad spectrum of changes outside the lung. The remote effects are typically dose dependent and the mechanisms responsible for these effects are incompletely understood. New evidence indicates that nitric oxide inhalation leads to formation of new compounds which may be carried as thiol groups attached to protein in blood or act indirectly through nitrite metabolites. This review presents the mechanisms of inhaled nitric oxide conversion to active compounds/metabolites and discusses their actions beyond pulmonary circulation with special emphasis on the potential for systemic effects.

keywords:

ANESTEZJOLOGIA I INTENSYWNA TERAPIAInhaled nitric oxide effects outside the lungs – proven and possible mechanisms

Waldemar Goździk , Anna Goździk

respiratory system agents, nitric oxide, nitrite, S-ni­trosothiol, ischemia, reperfusion injury

ANESTEZJOLOGIA I INTENSYWNA TERAPIA
Inhaled nitric oxide effects outside the lungs – proven and possible mechanisms

Waldemar Goździk

,

Anna Goździk

respiratory system agents, nitric oxide, nitrite, S-nitrosothiol, ischemia, reperfusion injury