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Review paper

APOE AS A RISK FACTOR FOR ALZHEIMER'S DISEASE AND LIPID METABOLISM DISORDERS: MOLECULAR ANALYSIS

Ewa Kowalska
1
,
Łukasz Madej
1
,
Kacper Szafraniec
1
,
Jarosław Rachuna
1

  1. Department of Biobanking and Research, Regional Science and Technology Center, Chęciny, Poland
Health Prob Civil.
Online publish date: 2024/05/08
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1. Madnani RS. Alzheimer’s disease: a mini-review for the clinician. Front Neurol. 2023; 14. https://doi.org/10.3389/fneur.2023.1178588
2. Bomasang-Layno E, Bronsther R. Diagnosis and treatment of Alzheimer’s disease: an update. Dela J Public Health. 2021; 7. https://doi.org/10.32481/djph.2021.09.009
3. Barcikowska M, Barczak A, Gabryelewicz T, Gałązka-Sobotka M,
4. Gorzkowska A, Klimkowicz-Mrowiec A, et al. [National Health Fund on health. Alzheimer's disease and related diseases] [Internet]. Warsaw: National Health Fund; 2022 [access 2024 Feb 5]. Available from: https://ezdrowie.gov.pl/pobierz/raport_alzheimer (in Polish).
5. Dubois B, Hampel H, Feldman HH, Scheltens P, Aisen P, Andrieu S, et al. Preclinical Alzheimer’s disease: definition, natural history, and diagnostic criteria. Alzheimer’s and Dementia, 2016; 12: 292-323. https://doi.org/10.1016/j.jalz.2016.02.002
6. Barczak, A. The Early Diagnosis of Alzheimer’s Disease. Pediatria i Medycyna Rodzinna 2018, 14, 157–166. https://doi.org/10.15557/PiMR.2018.0016
7. Kloske CM, Barnum CJ, Batista AF, Bradshaw EM, Brickman AM, Bu G, et al. APOE and immunity: research highlights. Alzheimer’s and Dementia. 2023; 19: 2677-2696. https://doi.org/10.1002/alz.13020
8. Weisgraber KH, Mahley RW, Kowal RC, Herz J, Goldstein JL, Brown MS. Apolipoprotein C-I modulates the interaction of apolipoprotein e with β-migrating very low density lipoproteins (β-VLDL) and inhibits binding of β-VLDL to low density lipoprotein receptor-related protein. Journal of Biological Chemistry. 1990; 265: 22453-22459. https://doi.org/10.1016/S0021-9258(18)45726-2
9. Meyer MR, Tschanz JT, Norton MC, Welsh-Bohmer KA, Steffens DC, Wyse BW, et al. APOE genotype predicts when – not whether – one is predisposed to develop Alzheimer disease. Nat Genet. 1998; 19: 321-322. https://doi.org/10.1038/1206
10. Utermann G, Langenbeck U, Beisiegel U, Weber W. Genetics of the Apolipoprotein E system in man. Am J Hum Genet. 1980; 32(3): 339-347.
11. Riddell DR, Zhou H, Atchison K, Warwick HK, Atkinson PJ, Jefferson J, et al. Impact of Apolipoprotein E (ApoE) polymorphism on brain ApoE levels. Journal of Neuroscience. 2008, 28; 11445-11453. https://doi.org/10.1523/JNEUROSCI.1972-08.2008
12. Yamazaki Y, Zhao N, Caulfield TR, Liu CC, Bu G. Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies. Nat Rev Neurol. 2019; 15: 501-518. https://doi.org/10.1038/s41582-019-0228-7
13. Liehn EA, Ponomariov V, Diaconu R, Streata I, Ioana M, Crespo-Avilan GE, et al. Apolipoprotein E in cardiovascular diseases: novel aspects of an old-fashioned enigma. Arch Med Res. 2018; 49: 522-529. https://doi.org/10.1016/j.arcmed.2018.08.008
14. Kara E, Marks JD, Roe AD, Commins C, Fan Z, Calvo-Rodriguez M, et al. A flow cytometry–based in vitro assay reveals that formation of Apolipoprotein E (ApoE)–amyloid beta complexes depends on ApoE isoform and cell type. Journal of Biological Chemistry. 2018; 293: 13247-13256. https://doi.org/10.1074/jbc.RA117.001388
15. Liu S, Liu J, Weng R, Gu X, Zhong Z. Apolipoprotein E gene polymorphism and the risk of cardiovascular disease and type 2 diabetes. BMC Cardiovasc Disord. 2019; 19. https://doi.org/10.1186/s12872-019-1194-0
16. Mahley RW. Apolipoprotein E: from cardiovascular disease to neurodegenerative disorders. J Mol Med. 2016; 94: 739-746. https://doi.org/10.1007/s00109-016-1427-y
17. Chen F, Ke Q, Wei W, Cui L, Wang Y. Apolipoprotein E and viral infection: risks and mechanisms. Mol Ther Nucleic Acids. 2023; 33: 529-542. https://doi.org/10.1016/j.omtn.2023.07.031
18. Hauser PS, Ryan RO. Impact of Apolipoprotein E on Alzheimer’s disease. Curr Alzheimer Res. 2013; 10(8): 809-817. https://doi.org/10.2174/15672050113109990156
19. Yang LG, March ZM, Stephenson RA, Narayan PS. Apolipoprotein E in lipid metabolism and neurodegenerative disease. Trends in Endocrinology and Metabolism. 2023; 34: 430-445. https://doi.org/10.1016/j.tem.2023.05.002
20. Rall SC, Mahley RW. The role of Apolipoprotein E genetic variants in lipoprotein disorders. J Intern Med. 1992; 231: 653-659. https://doi.org/10.1111/j.1365-2796.1992.tb01254.x
21. Evans D, Bode A, Lippe der von G, Beli FU, Mann WA. Cerebrovascular atherosclerosis in type iii hyperlipidemia is modulated by variation in the Apolipoprotein A5 gene. Eur J Med Res. 2011; 16: 79-84. https://doi.org/10.1186/2047-783X-16-2-79
22. Marais AD, Solomon GAE, Blom DJ. Dysbetalipoproteinaemia: A mixed hyperlipidaemia of remnant lipoproteins due to mutations in Apolipoprotein E. Crit Rev Clin Lab Sci. 2014; 51: 46-62. https://doi.org/10.3109/10408363.2013.870526
23. Kucharska E. [Arteriosclerosis – selected aspects]. Przegl. Lek. 2014; 71: 400-402 (in Polish).
24. Caetano AP. Anemia Investigation reveals a primary sea-blue histiocyte syndrome. International Journal of Pathology and Clinical Research. 2016; 2. https://doi.org/10.23937/2469-5807/1510019
25. Nguyen TT, Kruckeberg KE, O’Brien JF, Ji ZS, Karnes PS, Crotty TB, et al. Familial splenomegaly: macrophage hypercatabolism of lipoproteins associated with Apolipoprotein E mutation [Apolipoprotein E (149 Leu)]. J Clin Endocrinol Metab. 2000; 85(11): 4354-4358. https://doi.org/10.1210/jcem.85.11.6981
26. Mosca S, Araújo G, Costa V, Correia J, Bandeira A, Martins E, et al. Dyslipidemia diagnosis and treatment: risk stratification in children and adolescents. J Nutr Metab. 2022; 2022: 1-10. https://doi.org/10.1155/2022/4782344
27. Jones NS, Rebeck GW. The synergistic effects of APOE genotype and obesity on Alzheimer’s disease risk. Int J Mol Sci. 2019; 20(1): 63. https://doi.org/10.3390/ijms20010063
28. Kypreos KE, Karagiannides I, Fotiadou EH, Karavia EA, Brinkmeier MS, Giakoumi SM, et al. Mechanisms of obesity and related pathologies: role of Apolipoprotein E in the development of obesity. FEBS J. 2009; 276: 5720-5728. https://doi.org/10.1111/j.1742-4658.2009.07301.x
29. Wei X, Yan-Lin M, Chi C, Sheng-Miao F, Jin-Ju Z, Shui-Ping Y, et al. Apolipoprotein E gene expression in peripheral blood monocyte in children with obesity. Zhonghua Er Ke Za Zhi. 2003; 41(10): 755-760.
30. Silva MVF, Loures CD, Alves LC, De Souza LC, Borges KB, Carvalho MD. Alzheimer’s disease: risk factors and potentially protective measures. J Biomed Sci. 2019; 26. https://doi.org/10.1186/s12929-019-0524-y
31. Hausz-Piskorz B, .; Buczkowski, K. “Diagnostyka i leczenie choroby Alzheimera w warunkach praktyki lekarza rodzinnego”, Forum Medycyny Rodzinnej 2013, tom 7, nr 4, 198–207
32. Michaelson DM. APOE Ε4: the most prevalent yet understudied risk factor for Alzheimer’s disease. Alzheimer’s and Dementia. 2014; 10: 861-868. https://doi.org/10.1016/j.jalz.2014.06.015
33. Chávez-Fumagalli MA, Shrivastava P, Aguilar-Pineda JA, Nieto-Montesinos R, Del-Carpio GD, Peralta-Mestas A, et al. Diagnosis of Alzheimer’s disease in developed and developing countries: systematic review and meta-analysis of diagnostic test accuracy. J Alzheimers Dis Rep. 2021; 5: 15-30. https://doi.org/10.3233/ADR-200263
34. Porsteinsson AP, Isaacson RS, Knox S, Sabbagh MN, Rubino I. Diagnosis of early Alzheimer’s disease: clinical practice in 2021. Journal of Prevention of Alzheimer’s Disease. 2021; 8: 371-386. https://doi.org/10.14283/jpad.2021.23
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