REVIEW PAPER<BR>The genetics of melanoma

Urszula Brudnik; Anna Wojas-Pelc; Wojciech Branicki

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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1/2006
vol. 23

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abstract:

REVIEW PAPER
The genetics of melanoma

Urszula Brudnik

,

Anna Wojas-Pelc

,

Wojciech Branicki

Post Dermatol Alergol 2006; XXIII, 1: 21–25

Online publish date: 2006/02/24

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Melanoma is an important public health issue and research strategies are trying to elucidate the relative contribution of genes and environmental factors in its causation. In terms of genetic factors the discovery of cell cycle genes – CDKN2a, CDK4 – has been a great advance. Current studies aim to identify other susceptibility genes and to determine the interactions of the various genetic and environmental factors. Among them, MC1R (Melanocortin-1 receptor gene), PTEN, BRAF, NRAS are being analysed more closely. Epistatic (gene-gene) and gene environmental interactions studies aim to recognize individuals at high risk.

keywords:

REVIEW PAPERThe genetics of melanoma

Urszula Brudnik , Anna Wojas-Pelc , Wojciech Branicki

melanoma, genetics, CDKN2a, MC1R

REVIEW PAPER
The genetics of melanoma

Urszula Brudnik

,

Anna Wojas-Pelc

,

Wojciech Branicki