Actinic keratosis: comprehensive review of current treatments and emerging therapeutic innovations

Justyna Ceryn; Aleksandra Lesiak; Dorota Sobolewska-Sztychny; Marcin Noweta; Magdalena Ciążyńska; Joanna Narbutt

doi:10.5114/ada.2024.147331

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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abstract:

Review paper

Actinic keratosis: comprehensive review of current treatments and emerging therapeutic innovations

Justyna Ceryn

¹

,

Aleksandra Lesiak

¹

,

Dorota Sobolewska-Sztychny

¹

,

Marcin Noweta

¹

,

Magdalena Ciążyńska

¹

,

Joanna Narbutt

¹

Department of Dermatology, Paediatric Dermatology and Oncology Clinic, Medical University of Lodz, Poland

Adv Dermatol Allergol

DOI: https://doi.org/10.5114/ada.2024.147331

Online publish date: 2025/01/31

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Actinic keratosis (AK) is a prevalent benign intraepidermal dysplasia, classified as squamous cell carcinoma in situ (SCC in situ). Chronic ultraviolet (UV) light exposure is the primary etiological factor for AK, which predominantly manifests in sun-exposed areas. Management of AK emphasizes primary prevention through education, sun protection, and vigilant patient monitoring. Therapeutic strategies for AK are categorized into lesion-directed and field-directed approaches, encompassing topical treatments (imiquimod, 5-fluorouracil, diclofenac) and physical modalities (cryotherapy, photodynamic therapy, chemical peels, laser therapy, electrocoagulation, curettage). This comprehensive review discusses the current treatments and explores novel therapeutic options for AK.

keywords:

Actinic keratosis: comprehensive review of current treatments and emerging therapeutic innovations

Justyna Ceryn 1 , Aleksandra Lesiak 1 , Dorota Sobolewska-Sztychny 1 , Marcin Noweta 1 , Magdalena Ciążyńska 1 , Joanna Narbutt 1

actinic keratosis, systematic review, treatment

Justyna Ceryn

¹

,

Aleksandra Lesiak

¹

,

Dorota Sobolewska-Sztychny

¹

,

Marcin Noweta

¹

,

Magdalena Ciążyńska

¹

,

Joanna Narbutt

¹