Activation of the P38-MSK1 axis in colorectal adenocarcinoma determines a good prognostic outcome

Mariana F. Gayyed; Medhat Monir Soliman; Magdy Fouad Ahmed; Taha Mohamed Hassanin; Rajai Munir Al Jehani; Fatma El Zahraa Ammar Mohamed

doi:10.5114/pjp.2021.106442

eISSN: 2084-9869
ISSN: 1233-9687

Polish Journal of Pathology

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1/2021
vol. 72

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abstract:

Original paper

Activation of the P38-MSK1 axis in colorectal adenocarcinoma determines a good prognostic outcome

Mariana F. Gayyed

¹

,

Medhat Monir Soliman

²

,

Magdy Fouad Ahmed

³

,

Taha Mohamed Hassanin

³

,

Rajai Munir Al Jehani

⁴

,

Fatma El Zahraa Ammar Mohamed

¹

Assistant professor of Pathology, Faculty of Medicine, Minia University, Minia, Egypt
Consultant of Onco-surgery, Minia Oncology Centre, Minia, Egypt
Assistant professor of Tropical Medicine, Faculty of Medicine, Minia University, Minia, Egypt
Biomedical Scientist, UCL Institute for Liver and Digestive Health, Royal Free London NHS Foundation Trust, London, UK

Pol J Pathol 2021; 72 (1): 39-47

DOI: https://doi.org/10.5114/pjp.2021.106442

Online publish date: 2021/05/31

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Colorectal cancer (CRC) is the third most common cancer worldwide and is associated with a high level of mortality and morbidity. In this study we evaluate expression of p-p38 and p-MSK1 in CRC and determine whether there is an association between expression of these markers and any clinicopathologic parameters that could be of prognostic value.

Expression of p-p38, p-MSK1 and ki-67 were examined by immunohistochemistry in 135 archival CRC cases and the findings were correlated with the patient clinicopathological data.

P-p38 and p-MSK1 were expressed at high level in 58.5 % and 60.7% of CRC cases respectively. A statistically significant negative correlation was found between expression of p-p38 and Ki-67 (p < 0.001, r = –0.63) and between p-MSK1 and Ki-67 expression (p < 0.001, r = –0.61). The majority of CRC cases expressing high levels of p-p38 also expressed high levels of p-MSK1 and this correlation was highly significant (p < 0.001, r = 0.863). The high expression of p-p38 and p-MSK1 was also significantly associated with low Dukes and TNM stage. The elevated expression of p-38 and p-MSK1 in CRC was associated with a good prognosis and prolonged overall survival (p < 0.001, each).

Our finding showed that activation of the p38-MSK1 axis determines a good outcome in CRC.

keywords:

Activation of the P38-MSK1 axis in colorectal adenocarcinoma determines a good prognostic outcome

Mariana F. Gayyed 1 , Medhat Monir Soliman 2 , Magdy Fouad Ahmed 3 , Taha Mohamed Hassanin 3 , Rajai Munir Al Jehani 4 , Fatma El Zahraa Ammar Mohamed 1

colon adenocarcinoma, p-p38 and p-MSK1, Ki-67

Mariana F. Gayyed

¹

,

Medhat Monir Soliman

²

,

Magdy Fouad Ahmed

³

,

Taha Mohamed Hassanin

³

,

Rajai Munir Al Jehani

⁴

,

Fatma El Zahraa Ammar Mohamed

¹