Activation of the glymphatic system during sleep – is the cerebral venous outflow a missing piece of the puzzle?

Marian Simka

doi:10.5114/pr.2019.93400

eISSN: 1509-5738
ISSN: 1232-7174

Phlebological Review

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1/2019
vol. 27

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abstract:

Editorial

Activation of the glymphatic system during sleep – is the cerebral venous outflow a missing piece of the puzzle?

Marian Simka

¹

Department of Anatomy, Faculty of Medicine, University of Opole, Opole, Poland

Phlebological Review 2019; 27, 1: 1-2

DOI: https://doi.org/10.5114/pr.2019.93400

Online publish date: 2020/03/12

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Until recently, mechanisms responsible for an activation of the glymphatic system of the brain, the system which is responsible for cleansing of this organ of waste products, were unclear. A recently published paper has finally shed some light on this problem. It has been demonstrated that there is a temporary decrease of the arterial cerebral blood flow during the deep phase of sleep, which is followed by an influx of the cerebrospinal fluid into the cranial cavity, and that this phenomenon is probably responsible for the activation of the glymphatic system. Although, of as yet, this issue has not been studied, it is likely that such a mechanism is not effective in the settings of disturbed cerebral venous outflow, and that in the case of venous congestion inside the cranial cavity, neurodegenerative lesions may develop. Therefore, the investigations on cerebral venous haemodynamics in the context of proper functioning of the glymphatic system should be one the directions of future research.

keywords:

Activation of the glymphatic system during sleep – is the cerebral venous outflow a missing piece of the puzzle?

Marian Simka 1

glymphatic system, chronic cerebrospinal venous insufficiency, internal jugular vein

Marian Simka

¹