Adrenal metastases – long-term results of surgical treatment, single-centre experience

Radosław Samsel; Andrzej Cichocki; Katarzyna Roszkowska-Purska; Lucyna Papierska; Agnieszka Koalasińska-Ćwikła; Edyta Karpeta; Tomasz Ostrowski; Karolina Nowak

doi:10.5114/wo.2020.93679

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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1/2020
vol. 24

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abstract:

Original paper

Adrenal metastases – long-term results of surgical treatment, single-centre experience

Radosław Samsel

¹

,

Andrzej Cichocki

¹

,

Katarzyna Roszkowska-Purska

²

,

Lucyna Papierska

³

,

Agnieszka Koalasińska-Ćwikła

⁴

,

Edyta Karpeta

^{5, 6}

,

Tomasz Ostrowski

¹

,

Karolina Nowak

³

Department of Surgery, Clinic of Oncological Surgery and Neuroendocrine Tumors, Maria Sklodowska-Curie Institute – Oncology Center, Warsaw, Poland
Department of Pathology, Maria Sklodowska-Curie Institute – Oncology Center, Warsaw, Poland
Department of Endocrinology, Centre of Postgraduate Medical Education, Bielański Hospital, Warsaw, Poland
Department of Oncology and Radiotherapy, Maria Sklodowska-Curie Institute – Oncology Center, Warsaw, Poland
Department of General and Transplant Surgery, Infant Jesus Teaching Hospital, Warsaw, Poland
Department of Surgical and Transplantation Nursing and Extracorporeal Therapies, Medical University of Warsaw, Warsaw, Poland

Contemp Oncol (Pozn) 2020; 24 (1): 29-33

DOI: https://doi.org/10.5114/wo.2020.93679

Online publish date: 2020/03/13

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Introduction
The adrenal gland is a frequent site of metastases in different types of cancer. The aim of this study was to assess the results of metastatic adrenalectomy in a single institution and to identify factors for survival.

Material and methods
A retrospective, single-centre analysis of outcomes of 39 patients (22 male, 17 female) with adrenal metastases who underwent surgery within 14 years (2004–2017) was performed. The median age at the time of adrenal surgery was 64.8 years (range 49–79 years).

Results
In our study group non-small cell lung cancer (NSCLC) was the most frequent primary tumour type (15 pts), followed by renal cell carcinoma (RCC) (14 pts) and colon cancer (6 pts). Most of the metastases – 36 (92%) – were metachronous (> 6 months). All synchronous metastases were NSCLC. The mean time from primary cancer to adrenalectomy was 42.3 months (range 1–176) and was statistically longer for RCC. In 3 patients (8%) metastases were bilateral and both adrenal glands were removed. In all patients, surgery was limited to the adrenal gland, and no major complications of surgery were observed. The median overall survival after metastasectomy was 18 months (3–81) and was statistically longer for colon cancer – 29.5 months (p = 0.012). In patients who died, tumours were significantly bigger than in survivors, 76.5 mm vs. 52.5 mm (p = 0.026).

Conclusions
Surgery for adrenal metastasis is safe and indications for this procedure should be individualized. In selected patients, surgical removal of adrenal metastasis was associated with longer survival.

keywords:

Adrenal metastases – long-term results of surgical treatment, single-centre experience

Radosław Samsel 1 , Andrzej Cichocki 1 , Katarzyna Roszkowska-Purska 2 , Lucyna Papierska 3 , Agnieszka Koalasińska-Ćwikła 4 , Edyta Karpeta 5, 6 , Tomasz Ostrowski 1 , Karolina Nowak 3

adrenalectomy, adrenal metastases, adrenal mass, median overall survival

Radosław Samsel

¹

,

Andrzej Cichocki

¹

,

Katarzyna Roszkowska-Purska

²

,

Lucyna Papierska

³

,

Agnieszka Koalasińska-Ćwikła

⁴

,

Edyta Karpeta

^{5, 6}

,

Tomasz Ostrowski

¹

,

Karolina Nowak

³