Adult pneumococcal vaccination – new opportunities

Ernest Kuchar; Joanna Chorostowska-Wynimko; Leszek Czupryniak; Andrzej Fal; Robert Flisiak; Artur Mamcarz; Aneta Nitsch-Osuch; Anna Skoczyńska; Marcin Stajszczyk; Jacek Wysocki; Michał Abendort; Dominik Golicki; Katarzyna Jaśkowiak; Adam Antczak

doi:10.5114/fmpcr.2023.125500

eISSN: 2449-8580
ISSN: 1734-3402

Family Medicine & Primary Care Review

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1/2023
vol. 25

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abstract:

Review paper

Adult pneumococcal vaccination – new opportunities

Ernest Kuchar

¹

,

Joanna Chorostowska-Wynimko

²

,

Leszek Czupryniak

³

,

Andrzej Fal

^{4, 5}

,

Robert Flisiak

⁶

,

Artur Mamcarz

⁷

,

Aneta Nitsch-Osuch

⁸

,

Anna Skoczyńska

⁹

,

Marcin Stajszczyk

¹⁰

,

Jacek Wysocki

¹¹

,

Michał Abendort

¹²

,

Dominik Golicki

¹³

,

Katarzyna Jaśkowiak

¹⁴

,

Adam Antczak

¹⁵

Department of Paediatrics with Clinical Assessment Unit, Medical University of Warsaw, Warsaw, Poland
Department of Genetics and Clinical Immunology, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland
Department of Diabetology and Internal Medicine, Medical University of Warsaw, Warsaw, Poland
Department of Allergology, Lung Diseases and Internal Diseases, Central Clinical Hospital of the Ministry of Interior and Admin-istration, Warsaw, Poland
Faculty of Medicine, Collegium Medicum, Cardinal Stefan Wyszynski University, Warsaw, Poland
Department of Infectious Diseases and Hepatology, Medical University of Bialystok, Bialystok, Poland
3rd Department of Internal Diseases and Cardiology, Faculty of Medicine, Medical University of Warsaw, Warsaw, Poland
Department of Social Medicine and Public Health, Medical University of Warsaw, Warsaw, Poland
National Reference Centre for Bacterial Meningitis (KOROUN), Department of Epidemiology and Clinical Microbiology, National Medicines Institute, Warsaw, Poland
Department of Rheumatology and Autoimmune Diseases, Silesian Centre for Rheumatology, Orthopaedics and Rehabilitation, Ustron, Poland
Chair and Department of Health Prevention, Faculty of Health Sciences Poznan University of Medical Sciences, Poznan, Poland
Pfizer Polska Sp. z o.o., Warsaw, Poland
Chair and Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Warsaw, Poland
HealthQuest Sp. z o.o., Warsaw, Poland
Department of General and Oncological Pulmonology, Medical University of Lodz, Lodz, Poland

Family Medicine & Primary Care Review 2023; 25(1): 93–101

DOI: https://doi.org/10.5114/fmpcr.2023.125500

Online publish date: 2023/03/31

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Pneumococcal infections (Streptococcus pneumoniae) remain a significant epidemiological problem globally. Although an invasive pneumo-coccal disease (IPD), which includes meningitis, sepsis and pneumonia with bacteremia, is the most severe form of pneumococcal infection, the main bur-den in terms of morbidity and mortality is associated with community-acquired pneumonia in the elderly. The epidemiology of infections caused by S. pneumoniae serotypes can change naturally in time and by universal vaccination implementation. The proportion of infections caused by serotypes not contained in any available vaccines is constantly increasing. These changes stimulate the development of new vaccines and ensure the broadest possible protection against S. pneumoniae infections. There is a need to raise awareness of the burden of pneumococcal disease in adults and the vaccines used for prophylaxis for pneumococcal infection.

The article discusses the pneumococcal infection burden in the adult population and the factors that raise the risk of infections. We characterised available vaccines for adults, highlighting the significant differences between the conjugated and unconjugated polysaccharide vaccines. Current epidemiological data on pneumococcal infections in Europe and Poland is presented. The latest 20-valent pneumococcal conjugate vaccine (PCV20) is described, and the most recent Advisory Committee on Immunization Practices (ACIP) recommendations on primary prevention and the current implementation of vaccination against pneumococcal infections in the adult population in Poland are discussed.

keywords:

Adult pneumococcal vaccination – new opportunities

Ernest Kuchar 1 , Joanna Chorostowska-Wynimko 2 , Leszek Czupryniak 3 , Andrzej Fal 4, 5 , Robert Flisiak 6 , Artur Mamcarz 7 , Aneta Nitsch-Osuch 8 , Anna Skoczyńska 9 , Marcin Stajszczyk 10 , Jacek Wysocki 11 , Michał Abendort 12 , Dominik Golicki 13 , Katarzyna Jaśkowiak 14 , Adam Antczak 15

Streptococcus pneumoniae, pneumococcal vaccines, adult