Alterations in programmed cell death mechanism and their role in the pathogenesis of inflammatory bowel diseases

Piotr Eder; Liliana Łykowska-Szuber; Kamila Stawczyk-Eder; Iwona Krela-Kaźmierczak; Krzysztof Linke

doi:10.5114/pg.2014.46162

eISSN: 1897-4317
ISSN: 1895-5770

Gastroenterology Review/Przegląd Gastroenterologiczny

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5/2014
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abstract:

Review paper

Alterations in programmed cell death mechanism and their role in the pathogenesis of inflammatory bowel diseases

Piotr Eder

,

Liliana Łykowska-Szuber

,

Kamila Stawczyk-Eder

,

Iwona Krela-Kaźmierczak

,

Krzysztof Linke

Prz Gastroenterol 2014; 9 (5): 275–279

DOI: https://doi.org/10.5114/pg.2014.46162

Online publish date: 2014/10/19

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AMA

Eder P, Łykowska-Szuber L, Stawczyk-Eder K, Krela-Kaźmierczak I, Linke K. Alterations in programmed cell death mechanism and their role in the pathogenesis of inflammatory bowel diseases. Gastroenterology Review/Przegląd Gastroenterologiczny. 2014;9(5):275-279. doi:10.5114/pg.2014.46162.

APA

Eder, P., Łykowska-Szuber, L., Stawczyk-Eder, K., Krela-Kaźmierczak, I.,  & Linke, K. (2014). Alterations in programmed cell death mechanism and their role in the pathogenesis of inflammatory bowel diseases. Gastroenterology Review/Przegląd Gastroenterologiczny, 9(5), 275-279. https://doi.org/10.5114/pg.2014.46162

Chicago

Eder, Piotr, Liliana Łykowska-Szuber, Kamila Stawczyk-Eder, Iwona Krela-Kaźmierczak,  and Krzysztof Linke. 2014. "Alterations in programmed cell death mechanism and their role in the pathogenesis of inflammatory bowel diseases". Gastroenterology Review/Przegląd Gastroenterologiczny 9 (5): 275-279. doi:10.5114/pg.2014.46162.

Harvard

Eder, P., Łykowska-Szuber, L., Stawczyk-Eder, K., Krela-Kaźmierczak, I.,  and Linke, K. (2014). Alterations in programmed cell death mechanism and their role in the pathogenesis of inflammatory bowel diseases. Gastroenterology Review/Przegląd Gastroenterologiczny, 9(5), pp.275-279. https://doi.org/10.5114/pg.2014.46162

MLA

Eder, Piotr et al. "Alterations in programmed cell death mechanism and their role in the pathogenesis of inflammatory bowel diseases." Gastroenterology Review/Przegląd Gastroenterologiczny, vol. 9, no. 5, 2014, pp. 275-279. doi:10.5114/pg.2014.46162.

Vancouver

Eder P, Łykowska-Szuber L, Stawczyk-Eder K, Krela-Kaźmierczak I, Linke K. Alterations in programmed cell death mechanism and their role in the pathogenesis of inflammatory bowel diseases. Gastroenterology Review/Przegląd Gastroenterologiczny. 2014;9(5):275-279. doi:10.5114/pg.2014.46162.

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Apoptosis plays an essential role in both physiology and pathology. In the pathogenesis of inflammatory bowel diseases, disturbances of apoptosis also play an important role. Inflammatory cells (for example lymphocytes, granulocytes) in the gut wall are resistant to apoptotic stimuli and they accumulate there causing tissue damage. On the other hand, apoptotic elimination of the enterocytes is enhanced, which leads to the impairment of the gut barrier. The exact mechanisms of these phenomena are still poorly understood and they are still under investigation. The present paper summarises current knowledge in terms of the role of alterations of programmed cell death in the pathogenesis of inflammatory bowel diseases.

keywords:

Alterations in programmed cell death mechanism and their role in the pathogenesis of inflammatory bowel diseases

Piotr Eder , Liliana Łykowska-Szuber , Kamila Stawczyk-Eder , Iwona Krela-Kaźmierczak , Krzysztof Linke

inflammatory bowel diseases, apoptosis, lymphocytes, enterocytes

Piotr Eder

,

Liliana Łykowska-Szuber

,

Kamila Stawczyk-Eder

,

Iwona Krela-Kaźmierczak

,

Krzysztof Linke