Alternative treatment of chemoresistant, recurrent or advanced ovarian cancer. Part II

Jacek R. Wilczyński; Beata Makuła

eISSN: 2299-0038
ISSN: 1643-8876

Menopause Review/Przegląd Menopauzalny

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5/2011
vol. 10

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abstract:

Review paper

Alternative treatment of chemoresistant, recurrent or advanced ovarian cancer. Part II

Jacek R. Wilczyński

,

Beata Makuła

Przegląd Menopauzalny 2011; 5: 363–367

Online publish date: 2011/11/05

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Lack of satisfactory efficacy of classical chemotherapy in ovarian tumours led to attempts of treatment based on use of small molecules able to modulate or inhibit intracellular pathways engaged in cell growth, proliferation and apoptosis. The paper presents clinical trials in ovarian cancer patients using such drugs as:

1) protein kinase inhibitors, 2) molecules interfering with DNA transcription and repair, 3) inhibitors of transcription factors NF-κB and HIF-1.

keywords:

Alternative treatment of chemoresistant, recurrent or advanced ovarian cancer. Part II

Jacek R. Wilczyński , Beata Makuła

ovarian cancer, PTKs, DNA, NF-κB, HIF-1

Jacek R. Wilczyński

,

Beata Makuła