An­gio­ge­nic ac­ti­vi­ty and VEGF le­vel in se­ra of dia­be­tic pa­tients
with non­-pr­ol­if­er­at­ive re­ti­no­pa­thy

Piotr Skopiński; Barbara Duda-Król; Anna Lipińska; Ewa Sommer; Joanna Chorostowska-Wynimko; Urszula Demkow; Jerzy Szaflik; Ewa Skopińska-Różewska; Ewa Struzik

eISSN: 2719-3209
ISSN: 0023-2157

Klinika Oczna / Acta Ophthalmologica Polonica Supplement

Current supplement Archive Acta Ophthalmologica Polonica

3/2004
vol. 106

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abstract:

Experimental research

Angiogenic activity and VEGF level in sera of diabetic patients with non-proliferative retinopathy

Piotr Skopiński

^{1, 2}

,

Barbara Duda-Król

³

,

Anna Lipińska

⁴

,

Ewa Sommer

⁵

,

Joanna Chorostowska-Wynimko

⁵

,

Urszula Demkow

⁵

,

Jerzy Szaflik

¹

,

Ewa Skopińska-Różewska

⁵

,

Ewa Struzik

¹

Z Katedry i Kliniki Okulistyki II Wydziału Lekarskiego Akademii Medycznej w Warszawie
Z Zakładu Histologii i Embriologii, Centrum Biostruktury
Z III Kliniki Chorób Wewnętrznych II Wydziału Lekarskiego Akademii Medycznej w Warszawie
Z Kliniki Chorób Wewnętrznych Oddziału Stomatologii Akademii Medycznej w Warszawie
Z Zakładu Diagnostyki Laboratoryjnej i Immunologii Instytutu Gruźlicy i Chorób Płuc w Warszawie

KLINIKA OCZNA 2004, Supl. 3: S421–S423

Online publish date: 2022/12/29

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EndNote

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AMA

Skopiński P, Duda-Król B, Lipińska A, et al. Angiogenic activity and VEGF level in sera of diabetic patients
with non-proliferative retinopathy. Klinika Oczna / Acta Ophthalmologica Polonica Supplement. 2004.

APA

Skopiński, P., Duda-Król, B., Lipińska, A., Sommer, E., Chorostowska-Wynimko, J.,  & Demkow, U. et al. (2004). Angiogenic activity and VEGF level in sera of diabetic patients
with non-proliferative retinopathy. Klinika Oczna / Acta Ophthalmologica Polonica Supplement.

Chicago

Skopiński, Piotr, Barbara Duda-Król, Anna Lipińska, Ewa Sommer, Joanna Chorostowska-Wynimko, Urszula Demkow,  and Jerzy Szaflik et al. 2004. "Angiogenic activity and VEGF level in sera of diabetic patients
with non-proliferative retinopathy". Klinika Oczna / Acta Ophthalmologica Polonica Supplement.

Harvard

Skopiński, P., Duda-Król, B., Lipińska, A., Sommer, E., Chorostowska-Wynimko, J., Demkow, U., Szaflik, J., Skopińska-Różewska, E.,  and Struzik, E. (2004). Angiogenic activity and VEGF level in sera of diabetic patients
with non-proliferative retinopathy. Klinika Oczna / Acta Ophthalmologica Polonica Supplement.

MLA

Skopiński, Piotr et al. "Angiogenic activity and VEGF level in sera of diabetic patients
with non-proliferative retinopathy." Klinika Oczna / Acta Ophthalmologica Polonica Supplement, 2004.

Vancouver

Skopiński P, Duda-Król B, Lipińska A, Sommer E, Chorostowska-Wynimko J, Demkow U et al. Angiogenic activity and VEGF level in sera of diabetic patients
with non-proliferative retinopathy. Klinika Oczna / Acta Ophthalmologica Polonica Supplement. 2004.

Diabetic retinopathy is one of the most common causes of blindness. The majority of studies concerning this problem were performed in patients with late stage of disease, demonstrating proliferative retinopathy, when malformations of retinal vessels became irreversible (1). Numerous angiogenic factors related to retinal angiogenesis have been described. Among them, VEGF is thought to be the major mediator of proliferative retinopathy (2,3,4). Our present study was performed on sera collected from patients with earlier stage of ocular complications, manifested as background retinopathy. We have believed that the knowledge of the earliest events leading to pathological angiogenesis may be valuable for establishing some prophylactic regimens. Sera of 22 persons with DM1, aged 33-70 years, 37 persons with DM2, aged 37-79 years, 51 healthy people, aged 22-80 years (as controls) were studied. Direct serum-induced cutaneous angiogenesis test in mice (SIA) was applied (5,6). VEGF concentration in sera was mesured by ELISA (R & D Systems) test. Angiogenic activity and VEGF concentration of DM1 patients sera were highly statistically lower than these parameters in DM2 patients and controls.

keywords:

An­gio­ge­nic ac­ti­vi­ty and VEGF le­vel in se­ra of dia­be­tic pa­tients with non­-pr­ol­if­er­at­ive re­ti­no­pa­thy

Piotr Skopiński 1, 2 , Barbara Duda-Król 3 , Anna Lipińska 4 , Ewa Sommer 5 , Joanna Chorostowska-Wynimko 5 , Urszula Demkow 5 , Jerzy Szaflik 1 , Ewa Skopińska-Różewska 5 , Ewa Struzik 1

angiogenesis, non-proliferative retinopathy, VEGF, diabetes type 1 (DM1) and type 2 (DM2)

Angiogenic activity and VEGF level in sera of diabetic patients with non-proliferative retinopathy

Piotr Skopiński

^{1, 2}

,

Barbara Duda-Król

³

,

Anna Lipińska

⁴

,

Ewa Sommer

⁵

,

Joanna Chorostowska-Wynimko

⁵

,

Urszula Demkow

⁵

,

Jerzy Szaflik

¹

,

Ewa Skopińska-Różewska

⁵

,

Ewa Struzik

¹