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ISSN: 1233-9687
Polish Journal of Pathology
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2/2016
vol. 67
 
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abstract:
Case report

An unusual case of IgA-dominant postinfectious glomerulonephritis: a case report and review of the literature

Małgorzata Wagrowska-Danilewicz
,
Marian Danilewicz
,
Iwona Fisiak
,
Joanna Piskorska

Pol J Pathol 2016; 67 (2): 179-182
DOI: https://doi.org/10.5114/pjp.2016.61455
Online publish date: 2016/08/02
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We report a case of IgA-dominant postinfectious glomerulonephritis in a 49-year-old man presenting with acute kidney injury, nephrotic range proteinuria and hematuria. He suffered from ischemic heart disease, cardiac insufficiency, mitral regurgitation, tricuspid insufficiency, septal aneurysm and hypertension. Renal biopsy revealed segmental and focal endocapillary and mesangial hypercellularity, and thickening of the glomerular capillary wall. Immunofluorescence showed co-dominant strong coarse granular immunostaining of IgA, IgG and C3 mainly along the glomerular capillary wall. On electron microscopy some large subepithelial hump-shaped deposits were present. In summary, this case demonstrates the presence of a broad spectrum of glomerular histological findings in postinfectious glomerulonephritis.
keywords:

IgA-dominant glomerulonephritis, postinfectious glomerulonephritis, renal biopsy
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