An unusual case of <i>epidermodysplasia verruciformis</i> with mild cutaneous involvement and extensive genital cancers

Joanna M. Sałkowska-Wanat; Leszek Trzeciak; Katarzyna Smolarczyk; Tomasz Pniewski; Rafał Płoski; Sławomir Majewski

doi:10.5114/dr.2016.60626

eISSN: 2084-9893
ISSN: 0033-2526

Dermatology Review/Przegląd Dermatologiczny

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3/2016
vol. 103

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abstract:

Original paper

**An unusual case of epidermodysplasia verruciformis with mild cutaneous involvement and extensive genital cancers**

Joanna M. Sałkowska-Wanat

,

Leszek Trzeciak

,

Katarzyna Smolarczyk

,

Tomasz Pniewski

,

Rafał Płoski

,

Sławomir Majewski

Przegl Dermatol 2016, 103, 218–221

DOI: https://doi.org/10.5114/dr.2016.60626

Online publish date: 2016/06/28

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AMA

Sałkowska-Wanat J, Trzeciak L, Smolarczyk K, Pniewski T, Płoski R, Majewski S. An unusual case of epidermodysplasia verruciformis with mild cutaneous involvement and extensive genital cancers. Dermatology Review/Przegląd Dermatologiczny. 2016;103(3):218-221. doi:10.5114/dr.2016.60626.

APA

Sałkowska-Wanat, J., Trzeciak, L., Smolarczyk, K., Pniewski, T., Płoski, R.,  & Majewski, S. (2016). An unusual case of epidermodysplasia verruciformis with mild cutaneous involvement and extensive genital cancers. Dermatology Review/Przegląd Dermatologiczny, 103(3), 218-221. https://doi.org/10.5114/dr.2016.60626

Chicago

Sałkowska-Wanat, Joanna M., Leszek Trzeciak, Katarzyna Smolarczyk, Tomasz Pniewski, Rafał Płoski,  and Sławomir Majewski. 2016. "An unusual case of epidermodysplasia verruciformis with mild cutaneous involvement and extensive genital cancers". Dermatology Review/Przegląd Dermatologiczny 103 (3): 218-221. doi:10.5114/dr.2016.60626.

Harvard

Sałkowska-Wanat, J., Trzeciak, L., Smolarczyk, K., Pniewski, T., Płoski, R.,  and Majewski, S. (2016). An unusual case of epidermodysplasia verruciformis with mild cutaneous involvement and extensive genital cancers. Dermatology Review/Przegląd Dermatologiczny, 103(3), pp.218-221. https://doi.org/10.5114/dr.2016.60626

MLA

Sałkowska-Wanat, Joanna M. et al. "An unusual case of epidermodysplasia verruciformis with mild cutaneous involvement and extensive genital cancers." Dermatology Review/Przegląd Dermatologiczny, vol. 103, no. 3, 2016, pp. 218-221. doi:10.5114/dr.2016.60626.

Vancouver

Sałkowska-Wanat J, Trzeciak L, Smolarczyk K, Pniewski T, Płoski R, Majewski S. An unusual case of epidermodysplasia verruciformis with mild cutaneous involvement and extensive genital cancers. Dermatology Review/Przegląd Dermatologiczny. 2016;103(3):218-221. doi:10.5114/dr.2016.60626.

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Introduction. Human papillomaviruses (HPV) consist of more than 120 subtypes of viruses, which can be divided into three main groups: skin subtypes, mucosal subtypes and types responsible for the occurrence of the skin lesions in autosomal recessive disorders such as epidermodysplasia verruciformis.

Objective. The aim of the study was to evaluate the correlation between the occurrence of epidermodysplasia verruciformis and the development of genital cancers.

Case report. We analyzed the case of a young woman suffering from epidermodysplasia verruciformis from 6 years of age, who at the age of 20 developed genital cancers with a severe clinical course resulting in amputation of the uterus, cervix, the top of the vagina and labia major and minor. In the patient we found a mutation in the EVER2 gene and we revealed the presence of EV-HPV type 5, 9, 17, and 20 in unusual genital locations associated with genital cancers.

Conclusions. It is possible that in the presented case the rapid and severe course of genital cancers was related to mutation in the EVER2 gene.

keywords:

An unusual case of epidermodysplasia verruciformis with mild cutaneous involvement and extensive genital cancers

Joanna M. Sałkowska-Wanat , Leszek Trzeciak , Katarzyna Smolarczyk , Tomasz Pniewski , Rafał Płoski , Sławomir Majewski

HPV, EVER, epidermodysplasia verruciformis

**An unusual case of epidermodysplasia verruciformis with mild cutaneous involvement and extensive genital cancers**

Joanna M. Sałkowska-Wanat

,

Leszek Trzeciak

,

Katarzyna Smolarczyk

,

Tomasz Pniewski

,

Rafał Płoski

,

Sławomir Majewski