An update on direct immunofluorescence for diagnosing dermatitis herpetiformis

Marian Dmochowski; Justyna Gornowicz-Porowska; Monika Bowszyc-Dmochowska

doi:10.5114/ada.2019.91415

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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6/2019
vol. 36

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abstract:

Review paper

An update on direct immunofluorescence for diagnosing dermatitis herpetiformis

Marian Dmochowski

¹

,

Justyna Gornowicz-Porowska

^{1, 2}

,

Monika Bowszyc-Dmochowska

³

Autoimmune Blistering Dermatoses Section, Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland
Department of Medicinal and Cosmetic Natural Products, Poznan University of Medical Sciences, Poznan, Poland
Cutaneous Histopathology and Immunopathology Section, Department of Dermatology, Poznan University of Medical Sciences, Poznan, Poland

Adv Dermatol Allergol 2019; XXXVI (6): 655-658

DOI: https://doi.org/10.5114/ada.2019.91415

Online publish date: 2019/12/30

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This mini-review presents an update on the direct immunofluorescence (DIF) for diagnosing dermatitis herpetiformis. The DIF of uninvolved, perilesional skin is a crucial laboratory procedure in diagnosing dermatitis herpetiformis (DH). IgA deposits at the dermal-epidermal junction (DEJ) of perilesional skin with DIF can also be found in coeliac patients with inflammatory skin diseases different from DH. In certain patients presenting with the rash resembling DH, the deposition of exclusively C3 at DEJ can be found. The term “granular C3 dermatosis” was proposed to name such a rash. Recent data on DH suggest that perhaps the very concept of DH that we are universally accepting now is misleading and should be revised.

keywords:

An update on direct immunofluorescence for diagnosing dermatitis herpetiformis

Marian Dmochowski 1 , Justyna Gornowicz-Porowska 1, 2 , Monika Bowszyc-Dmochowska 3

dermatitis herpetiformis, direct immunofluorescence, diagnosis

Marian Dmochowski

¹

,

Justyna Gornowicz-Porowska

^{1, 2}

,

Monika Bowszyc-Dmochowska

³