Analysis of selected pro- and anti-inflammatory cytokines in patients with multiple injuries 
in the early period after trauma

Gołąbek-Dropiewska K, Pawłowska J, Witkowski J, et al. Analysis of selected pro- and anti-inflammatory cytokines in patients with multiple injuries 
in the early period after trauma. Central European Journal of Immunology. 2018;43(1):42-49. doi:10.5114/ceji.2018.74872.

APA

Gołąbek-Dropiewska, K., Pawłowska, J., Witkowski, J., Lasek, J., Marks, W.,  & Stasiak, M. et al. (2018). Analysis of selected pro- and anti-inflammatory cytokines in patients with multiple injuries 
in the early period after trauma. Central European Journal of Immunology, 43(1), 42-49. https://doi.org/10.5114/ceji.2018.74872

Chicago

Gołąbek-Dropiewska, Katarzyna, Justyna Pawłowska, Jacek Witkowski, Jerzy Lasek, Wojciech Marks, Mariusz Stasiak,  and Dawid Jaskólski et al. 2018. "Analysis of selected pro- and anti-inflammatory cytokines in patients with multiple injuries 
in the early period after trauma". Central European Journal of Immunology 43 (1): 42-49. doi:10.5114/ceji.2018.74872.

Harvard

Gołąbek-Dropiewska, K., Pawłowska, J., Witkowski, J., Lasek, J., Marks, W., Stasiak, M., Jaskólski, D., Kawecka, A., Łuczkiewicz, P.,  and Baczkowski, B. (2018). Analysis of selected pro- and anti-inflammatory cytokines in patients with multiple injuries 
in the early period after trauma. Central European Journal of Immunology, 43(1), pp.42-49. https://doi.org/10.5114/ceji.2018.74872

MLA

Gołąbek-Dropiewska, Katarzyna et al. "Analysis of selected pro- and anti-inflammatory cytokines in patients with multiple injuries 
in the early period after trauma." Central European Journal of Immunology, vol. 43, no. 1, 2018, pp. 42-49. doi:10.5114/ceji.2018.74872.

Vancouver

Gołąbek-Dropiewska K, Pawłowska J, Witkowski J, Lasek J, Marks W, Stasiak M et al. Analysis of selected pro- and anti-inflammatory cytokines in patients with multiple injuries 
in the early period after trauma. Central European Journal of Immunology. 2018;43(1):42-49. doi:10.5114/ceji.2018.74872.

PlumX metrics:

Introduction
Severe trauma causes damage to the protective barriers of the organism, and thus activates immunological reaction. Among substances secreted during this process pro-inflammatory cytokines are of high importance.

The aim of the study
Severe trauma causing multiple injuries is more likely to lead to particularly intensive inflammatory reaction, which can sometimes lead to serious complications, even life-threatening. The aim of the study is to determine those parameters which may serve as predictors of infectious complications and to enable estimation of the patient’s immunological status before the decision to introduce elective procedures.

Material and methods
The study population included patients with multiple trauma treated in the Department of Trauma Surgery of the Medical University of Gdańsk. The severity of injuries was evaluated with commonly used numerical scales (Revised Trauma Score – RTS, Injury Severity Score – ISS, Glasgow Coma Scale – GCS). Blood samples were collected on the first, second, and fifth day after injury. Evaluated parameters: C-reactive protein (CRP), the level of cytokines: IL-8, IL-1, IL-6, TNF, IL-12p70, and IL-10. Control population: individuals without injury.

Results
Evaluation of IL-6, IL-8, and CRP levels in patients with multiple trauma in the early period after injury (2-3 days) could be considered as a predictor of delayed infection (5-10 days). CRP level, being cheap and commonly accessible, can be used in clinical practice enabling identification of patients at higher risk of infectious complications and introduction of appropriate treatment and prevention. The analysis of the mentioned parameters may contribute to choosing an appropriate management strategy, including “timing” depending on the patient’s biological status.

keywords:

Analysis of selected pro- and anti-inflammatory cytokines in patients with multiple injuries in the early period after trauma

Katarzyna Gołąbek-Dropiewska , Justyna Pawłowska , Jacek Witkowski , Jerzy Lasek , Wojciech Marks , Mariusz Stasiak , Dawid Jaskólski , Aleksandra Kawecka , Piotr Łuczkiewicz , Bogusław Baczkowski

cytokines, inflammation, CRP, infectious complications, multiple injuries

Katarzyna Gołąbek-Dropiewska

,

Justyna Pawłowska

,

Jacek Witkowski

,

Jerzy Lasek

,

Wojciech Marks

,

Mariusz Stasiak

,

Dawid Jaskólski

,

Aleksandra Kawecka

,

Piotr Łuczkiewicz

,

Bogusław Baczkowski