Aneurysm formation after paclitaxel-eluting balloon angioplasty used to treat coronary artery restenosis after plain old balloon angioplasty – case report and review of the literature

Introduction

We report the first case of coronary aneurysm formation after paclitaxel-eluting balloon angioplasty (PEBA) used to treat a coronary restenosis following previous balloon angioplasty.

Case report

A 58-year-old man with a history of arterial hypertension, dyslipidemia and active smoking was admitted to our institution in September 2011 for recurrent angina after previous plain old balloon angioplasty (POBA) in the left anterior descending artery 3 months previously (Figure 1 A, B). During the previous hospitalization, reduced left ventricular ejection fraction (32%), septo-apical aneurysm and apical thrombosis were found. The decision about POBA (and eventual bare metal stenting) was due to the need of oral anticoagulation, double antiplatelet therapy, small caliber of the reference vessel, high CRUSADE Bleeding Risk Score, and history of pyloric stenosis and traumatic subdural hematoma. There was a high-grade restenosis in the previously treated segments. A decision was made for repeated angioplasty with a drug-eluting balloon (DEB) (because of long-term risk from bleeding still deemed high for prolonged antithrombotic therapy after drug-eluting stent implantation and high risk of restenosis). Both lesions were predilated (2.5 × 20 mm semi-compliant balloon up to 8 atm). A 2.75 × 20 mm paclitaxel-eluting balloon (Dior, Eurocor GmbH, Germany) was inflated at 8 atm for 30 s in the distal lesion and the same balloon was then inflated to 10 atm for another 30” in the proximal lesion. The final angiographic result was good and the patient was scheduled for angiographic follow-up after 3 months (routine at our institution for all patients treated with drug-eluting balloons).
The patient came back to our department at the end of January 2012. A non-significant restenosis of the distal lesion and no restenosis of the proximal lesion were present. However, the angiogram revealed a coronary aneurysm in the distal segment, at the site of the first inflation of the DEB (Figure 1 C, D). Both the angiogram and the echocardiogram of the left ventricle of the patient showed persistent septo-apical aneurysm, but with no signs of intracavitary thrombus. He was discharged on the following day and left on triple antithrombotic therapy for the next 3 months and then was advised to take double antiplatelet therapy for 6 more months (as the ischemic risk from local aneurysm thrombosis was considered as high).

Discussion

To the...


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