Anomalies of ErbB (HER) receptor functions: mechanisms and methods of detection. Part I. Gene amplification of ErbB (HER) family

Bogdan Falkiewicz; Burkhard H. Brandt; Krzysztof P. Bielawski; Ulf Vogt

eISSN: 1897-4309
ISSN: 1428-2526

Contemporary Oncology/Współczesna Onkologia

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3/2000
vol. 4

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abstract:

**Anomalies of ErbB (HER) receptor functions: mechanisms and methods of detection. Part I. Gene amplification of ErbB (HER) family**

Bogdan Falkiewicz

,

Burkhard H. Brandt

,

Krzysztof P. Bielawski

,

Ulf Vogt

Współcz Onkol (2000) vol. 4, 3 (102-107)

Online publish date: 2003/07/25

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The paper reviews mechanisms (gene amplifications, point mutations and deletions, gene expression alterations) leading to excessive activity of the ErbB (HER) family receptor tyrosine kinases, as well as techniques used in the research on these anomalies. Part I shortly describes the phenomenon of ErbB (HER) family gene amplification and methods used for its determination.

keywords:

Anomalies of ErbB (HER) receptor functions: mechanisms and methods of detection. Part I. Gene amplification of ErbB (HER) family

Bogdan Falkiewicz , Burkhard H. Brandt , Krzysztof P. Bielawski , Ulf Vogt

oncogenes, ErbB (HER) receptors, gene amplification, quantitative PCR

**Anomalies of ErbB (HER) receptor functions: mechanisms and methods of detection. Part I. Gene amplification of ErbB (HER) family**

Bogdan Falkiewicz

,

Burkhard H. Brandt

,

Krzysztof P. Bielawski

,

Ulf Vogt