Anomalous origin of right coronary artery from mid-left anterior descending artery leading to coronary steal phenomenon and ischemia

Coronary anomalies are usually diagnosed incidentally during coronary angiography. Anomalous origin of the right coronary artery (RCA) from the left anterior descending (LAD) is a rare clinical entity [1, 2]. Noninvasive anatomic assessment by coronary computed tomography (CT) angiography has evolved to become a highly accurate method in the diagnosis of coronary artery disease (CAD), comparable to conventional invasive coronary angiography [3]. We report a case of anomalous RCA originating from the mid-LAD leading to exertional dyspnea.
A 50-year-old woman was admitted to our cardiology outpatient clinic with the complaint of exertional dyspnea and atypical chest pain. The patient was not eligible for the treadmill stress test due to congenital hip dislocation. Therefore, we scheduled myocardial perfusion scintigraphy, and hypoperfusion was detected in the mid and basal segments of the anterior region of the heart (Figure 1). These changes were interpreted as mild ischemia. As further investigation, coronary CT angiography was scheduled for the patient. Coronary CT angiography demonstrated a single coronary artery from the left Valsalva sinus. An anomalous RCA originated from the mid-LAD, after the first diagonal branch, coursing to the right, anterior to the pulmonary artery, then trajecting downward into the right atrioventricular groove (Figures 2–4).
Anomalies of the RCA are observed to a relatively lesser extent. Yamanaka and Hobbs [4] reported anomalous RCA at the rate of 0.26% in a series of 126,595 patients. Turkmen et al. reported the incidence of single coronary artery anomaly as 0.031% in a series of 215,140 patients who underwent routine coronary angiography [5].
Although anomalous coronary artery is considered to be a benign entity, it may cause myocardial ischemia and even sudden cardiac death. Most of these patients are asymptomatic and have normal electrocardiograms at rest. However, ischemia may be precipitated by strenuous, prolonged physical activity. Our patient’s symptoms emerged only with exercise.
Myocardial ischemia should be excluded before a coronary anomaly is considered as benign. Myocardial perfusion scintigraphy is a useful and widespread method for indicating the presence of ischemia. Also, coronary CT angiography may be beneficial in the diagnosis of CAD and coronary anomalies. Coronary tomputed angiography demonstrated a single coronary artery anomaly in our patient (Figures 2–4). The coronary tree...


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