Antagonistic interaction of lacosamide with carbamazepine and valproate in the mouse tonic-clonic seizure model

Maria W. Kondrat-Wróbel; Katarzyna Załuska; Aleksandra Walczak; Anna N. Panasiuk-Poterek; Agata Gut-Lepiech; Paula Wróblewska-Łuczka; Jarogniew J. Łuszczki

doi:10.5114/hpc.2019.81105

eISSN: 2354-0265
ISSN: 2353-6942

Health Problems of Civilization Physical activity: diseases and issues recognized by the WHO

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abstract:

Original paper

Antagonistic interaction of lacosamide with carbamazepine and valproate in the mouse tonic-clonic seizure model

Maria W. Kondrat-Wróbel

¹

,

Katarzyna Załuska

¹

,

Aleksandra Walczak

¹

,

Anna N. Panasiuk-Poterek

¹

,

Agata Gut-Lepiech

¹

,

Paula Wróblewska-Łuczka

¹

,

Jarogniew J. Łuszczki

^{1, 2}

Department of Pathophysiology, Medical University of Lublin, Poland
Isobolographic Analysis Laboratory, Institute of Rural Health, Lublin, Poland

Health Prob Civil. 2019; 13(1): 92-98

DOI: https://doi.org/10.5114/hpc.2019.81105

Online publish date: 2019/01/30

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AMA

Kondrat-Wróbel M, Załuska K, Walczak A, et al. Antagonistic interaction of lacosamide with carbamazepine and valproate in the mouse tonic-clonic seizure model. Health Problems of Civilization. 2019;13(1):92-98. doi:10.5114/hpc.2019.81105.

APA

Kondrat-Wróbel, M., Załuska, K., Walczak, A., Panasiuk-Poterek, A., Gut-Lepiech, A.,  & Wróblewska-Łuczka, P. et al. (2019). Antagonistic interaction of lacosamide with carbamazepine and valproate in the mouse tonic-clonic seizure model. Health Problems of Civilization, 13(1), 92-98. https://doi.org/10.5114/hpc.2019.81105

Chicago

Kondrat-Wróbel, Maria W., Katarzyna Załuska, Aleksandra Walczak, Anna N. Panasiuk-Poterek, Agata Gut-Lepiech, Paula Wróblewska-Łuczka,  and Jarogniew J. Łuszczki. 2019. "Antagonistic interaction of lacosamide with carbamazepine and valproate in the mouse tonic-clonic seizure model". Health Problems of Civilization 13 (1): 92-98. doi:10.5114/hpc.2019.81105.

Harvard

Kondrat-Wróbel, M., Załuska, K., Walczak, A., Panasiuk-Poterek, A., Gut-Lepiech, A., Wróblewska-Łuczka, P.,  and Łuszczki, J. (2019). Antagonistic interaction of lacosamide with carbamazepine and valproate in the mouse tonic-clonic seizure model. Health Problems of Civilization, 13(1), pp.92-98. https://doi.org/10.5114/hpc.2019.81105

MLA

Kondrat-Wróbel, Maria W. et al. "Antagonistic interaction of lacosamide with carbamazepine and valproate in the mouse tonic-clonic seizure model." Health Problems of Civilization, vol. 13, no. 1, 2019, pp. 92-98. doi:10.5114/hpc.2019.81105.

Vancouver

Kondrat-Wróbel M, Załuska K, Walczak A, Panasiuk-Poterek A, Gut-Lepiech A, Wróblewska-Łuczka P et al. Antagonistic interaction of lacosamide with carbamazepine and valproate in the mouse tonic-clonic seizure model. Health Problems of Civilization. 2019;13(1):92-98. doi:10.5114/hpc.2019.81105.

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Background
It is estimated that approximately 1% of people worldwide suffer from epilepsy. Currently available antiepileptic drugs (AEDs) are able to control epileptic seizures in about 70% of cases. In the remaining patients (30%), the application of two or three AEDs in combination is necessary for effective seizure management. The goal of this work was to characterize the interaction of three AEDs: lacosamide (LCM), carbamazepine (CBZ) and valproate (VPA) at the fixed-ratio of 1:1:1 in the mouse tonic-clonic seizure model.

Material and methods
Male albino Swiss mice, after receiving a combination of LCM, CBZ and VPA, were challenged with electric current to evoke tonic hind limb extension (seizure activity). Protection of the mice from tonic-clonic seizures was assessed by isobolographic analysis to determine the type of interaction occurring between these drugs.

Results
Type I isobolographic analysis revealed that the combination of LCM, CBZ and VPA produced infra-additive (antagonistic) interaction in the mouse tonic-clonic seizure model.

Conclusions
Since the three-drug mixture of LCM, CBZ and VPA exerted an antagonistic interaction in the tonic-clonic seizure test in mice, we would caution physicians against treating epilepsy patients with this unfavorable combination.

keywords:

Antagonistic interaction of lacosamide with carbamazepine and valproate in the mouse tonic-clonic seizure model

Maria W. Kondrat-Wróbel 1 , Katarzyna Załuska 1 , Aleksandra Walczak 1 , Anna N. Panasiuk-Poterek 1 , Agata Gut-Lepiech 1 , Paula Wróblewska-Łuczka 1 , Jarogniew J. Łuszczki 1, 2

antiepileptic drugs, isobolography, maximal electroshock, three-drug combination, antagonism

Maria W. Kondrat-Wróbel

¹

,

Katarzyna Załuska

¹

,

Aleksandra Walczak

¹

,

Anna N. Panasiuk-Poterek

¹

,

Agata Gut-Lepiech

¹

,

Paula Wróblewska-Łuczka

¹

,

Jarogniew J. Łuszczki

^{1, 2}