Are interleukin-15 and -22 a new pathogenic factor in pustular palmoplantar psoriasis?

Aleksandra Lesiak; Igor Bednarski; Marta Pałczyńska; Ewelina Kumiszcza; Marzena Kraska-Gacka; Anna Woźniacka; Joanna Narbutt

doi:10.5114/ada.2016.62838

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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5/2016
vol. 33

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abstract:

Original paper

Are interleukin-15 and -22 a new pathogenic factor in pustular palmoplantar psoriasis?

Aleksandra Lesiak

,

Igor Bednarski

,

Marta Pałczyńska

,

Ewelina Kumiszcza

,

Marzena Kraska-Gacka

,

Anna Woźniacka

,

Joanna Narbutt

Adv Dermatol Allergol 2016; XXXIII (5): 336-339

DOI: https://doi.org/10.5114/ada.2016.62838

Online publish date: 2016/10/21

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AMA

Lesiak A, Bednarski I, Pałczyńska M, et al. Are interleukin-15 and -22 a new pathogenic factor in pustular palmoplantar psoriasis?. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2016;33(5):336-339. doi:10.5114/ada.2016.62838.

APA

Lesiak, A., Bednarski, I., Pałczyńska, M., Kumiszcza, E., Kraska-Gacka, M.,  & Woźniacka, A. et al. (2016). Are interleukin-15 and -22 a new pathogenic factor in pustular palmoplantar psoriasis?. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 33(5), 336-339. https://doi.org/10.5114/ada.2016.62838

Chicago

Lesiak, Aleksandra, Igor Bednarski, Marta Pałczyńska, Ewelina Kumiszcza, Marzena Kraska-Gacka, Anna Woźniacka,  and Joanna Narbutt. 2016. "Are interleukin-15 and -22 a new pathogenic factor in pustular palmoplantar psoriasis?". Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii 33 (5): 336-339. doi:10.5114/ada.2016.62838.

Harvard

Lesiak, A., Bednarski, I., Pałczyńska, M., Kumiszcza, E., Kraska-Gacka, M., Woźniacka, A.,  and Narbutt, J. (2016). Are interleukin-15 and -22 a new pathogenic factor in pustular palmoplantar psoriasis?. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 33(5), pp.336-339. https://doi.org/10.5114/ada.2016.62838

MLA

Lesiak, Aleksandra et al. "Are interleukin-15 and -22 a new pathogenic factor in pustular palmoplantar psoriasis?." Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, vol. 33, no. 5, 2016, pp. 336-339. doi:10.5114/ada.2016.62838.

Vancouver

Lesiak A, Bednarski I, Pałczyńska M, Kumiszcza E, Kraska-Gacka M, Woźniacka A et al. Are interleukin-15 and -22 a new pathogenic factor in pustular palmoplantar psoriasis?. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2016;33(5):336-339. doi:10.5114/ada.2016.62838.

Introduction: Pustular palmoplantar psoriasis (PPP) is a rare type of psoriasis affecting mainly distal parts of the limbs. Despite numerous theories about etiology of PPP, the pathogenesis still remains unclear. Recent data indicate that interleukin (IL)-15, IL-17 and IL-22 enhance a proinflammatory response in certain skin inflammatory diseases such as psoriasis and atopic dermatitis. There is also evidence that anti-endomysial (anti-EMA) and anti-gliadin (AGA) antibodies are engaged in PPP development.

Aim: To assess IL-15, IL-17, IL-22 serum levels and evaluate the presence of anti-endomysial and anti-gliadin antibodies in patients with PPP.

Material and methods: The study group consisted of 20 females of the mean age of 51.8 suffering from PPP. Additionally 29 healthy individuals, age and sex matched, served as controls. ELISA was performed to evaluate serum IL-15, IL-17, IL-22 concentrations while an indirect immunofluorescence test (IIF) was used to determine anti-EMA and AGA presence.

Results: The mean value of IL-15 and IL-22 serum concentrations was significantly higher in the study group than in the control group (IL-15: 6.48 vs. 4.88 pg/ml; IL-22: 81.47 vs. 4.90 pg/ml, respectively; p < 0.05 for all comparisons). The IL-17 serum level in the study group was higher when compared to the control group (2.0 vs. 0.75 pg/ml), however the results were not statistically significant (p = 0.26). There were no anti-EMA and AGA antibodies detected, both in the control and study group.

Conclusions: The results obtained may suggest involvement of IL-15 and IL-22 in the pathogenesis of PPP.

keywords:

Are interleukin-15 and -22 a new pathogenic factor in pustular palmoplantar psoriasis?

Aleksandra Lesiak , Igor Bednarski , Marta Pałczyńska , Ewelina Kumiszcza , Marzena Kraska-Gacka , Anna Woźniacka , Joanna Narbutt

interleukin 15, interleukin 17, interleukin 22, anti-endomysial antibodies, anti-gliadin antibodies, pustular palmoplantar psoriasis

Aleksandra Lesiak

,

Igor Bednarski

,

Marta Pałczyńska

,

Ewelina Kumiszcza

,

Marzena Kraska-Gacka

,

Anna Woźniacka

,

Joanna Narbutt