eISSN: 1897-4295
ISSN: 1734-9338
Advances in Interventional Cardiology/Postępy w Kardiologii Interwencyjnej
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3/2012
vol. 8
 
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abstract:

Original paper
Diagnostic accuracy of dual-source coronary computed tomography angiography in patients after bypass grafting

Cezary Kępka
,
Maksymilian Opolski
,
Mariusz Kruk
,
Jerzy Pręgowski
,
Anna Kowalewska
,
Paulina Wilkowska
,
Zofia Dzielińska
,
Maciej Karcz
,
Witold Rużyłło
,
Marcin Demkow

Postep Kardiol Inter 2012; 8, 3 (29): 183–192
Online publish date: 2012/09/17
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Aim: To determine the diagnostic accuracy of dual-source (DS) coronary computed tomography angiography (CCTA) with improved temporal resolution in a population of symptomatic patients after coronary artery bypass grafting (CABG) compared to invasive coronary angiography (ICA).

Material and methods: Ninety (74 male, mean age: 68 ±9 years) symptomatic post-CABG patients from the prospective ANIN Coronary Computed Tomography Angiography Registry who underwent both DS-CCTA and ICA for suspected graft disease were included in the analysis. A total of 202 grafts (67 arterial grafts, 135 venous grafts) and 1,105 segments in 360 native coronary arteries  1.5 mm in diameter were evaluated for the presence of significant stenosis, defined as  50% decrease in vessel diameter. Results were compared with ICA as the standard of reference.

Results: Sensitivity, specificity, and positive and negative predictive values of DS-CCTA for the detection of significant lesions in bypass grafts were 99%, 96%, 94%, and 99%, respectively. Segment-by-segment analysis of native coronary arteries for the detection of obstructive disease yielded sensitivity of 91% with specificity of 92%. If analysis was restricted to non-grafted and distal runoff segments, sensitivity and specificity were 88% and 96%, respectively. The presence of coronary calcium deposits was associated with a significant decrease in diagnostic accuracy of DS-CCTA.

Conclusions: The DS-CCTA allows reliable evaluation of suspected graft disease in symptomatic post-CABG patients, whereas ICA is still required for the assessment of significant stenoses in native coronary circulation.
keywords:

dual-source coronary computed tomography angiography, coronary artery bypass grafts, coronary artery disease

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