Review paper<br>Genital ulcer diseases as an entry for HIV infection

Monika Duś; Magdalena Łuczkowska; Ryszard Żaba

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

Current issue Archive Manuscripts accepted About the journal Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures

Editorial System

Submit your Manuscript

Editorial Policies

Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

4/2009
vol. 26

Send email

Copy url:

abstract:

Review paper
Genital ulcer diseases as an entry for HIV infection

Monika Duś

,

Magdalena Łuczkowska

,

Ryszard Żaba

Post Dermatol Alergol 2009; XXVI, 4: 206–211

Online publish date: 2009/08/30

View full text Get citation

Genital ulcer diseases (GUDs) are documented agents facilitating HIV-1 infection. The main pathogens causing GUDs are: Herpes simplex virus (HSV), Treponema pallidum and Haemophilus ducreyi. It is suggested that these diseases may increase the risk of HIV transmission even a hundredfold. A few mechanisms facilitating HIV penetration into the organism are considered. The first one is disruption of the epidermis or mucous membranes, creating a physical entry point for an infection. The next one is an increased number of inflammatory infiltration cells such as macrophages and T-lymphocytes. Increased expression (up-regulation) of HIV co-receptors – CCR5 and CXCR4 – on the surface of macrophages and lymphocytes in lesions is an additional risk factor of HIV infection. In the paper relationships between GUDs and HIV acquisition are described.

keywords:

Review paperGenital ulcer diseases as an entry for HIV infection

Monika Duś , Magdalena Łuczkowska , Ryszard Żaba

genital ulcers, HIV

Review paper
Genital ulcer diseases as an entry for HIV infection

Monika Duś

,

Magdalena Łuczkowska

,

Ryszard Żaba