Original papers<br>Polymorphism of the vascular endothelial growth factor gene and susceptibility to basal cell carcinoma – preliminary study

Michał Sobjanek; Monika Zabłotna; Igor Michajłowski; Marek Urban; Bogusław Nedoszytko; Wioletta Mędrzycka-Dąbrowska; Adam Włodarkiewicz; Jadwiga Roszkiewicz

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

Current issue Archive Manuscripts accepted About the journal Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures

Editorial System

Submit your Manuscript

Editorial Policies

Sarajevo Declaration on Integrity and Visibility of Scholarly Publications

2/2009
vol. 26

Send email

Copy url:

abstract:

Original papers
Polymorphism of the vascular endothelial growth factor gene and susceptibility to basal cell carcinoma – preliminary study

Michał Sobjanek

,

Monika Zabłotna

,

Igor Michajłowski

,

Marek Urban

,

Bogusław Nedoszytko

,

Wioletta Mędrzycka-Dąbrowska

,

Adam Włodarkiewicz

,

Jadwiga Roszkiewicz

Post Dermatol Alergol 2009; XXVI, 2: 71–73

Online publish date: 2009/04/27

View full text Get citation

EndNote

Papers, Reference Manager, RefWorks, Zotero

AMA

Sobjanek M, Zabłotna M, Michajłowski I, et al. Original papersPolymorphism of the vascular endothelial growth factor gene and susceptibility to basal cell carcinoma – preliminary study. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2009;26(2):71-73.

APA

Sobjanek, M., Zabłotna, M., Michajłowski, I., Urban, M., Nedoszytko, B.,  & Mędrzycka-Dąbrowska, W. et al. (2009). Original papersPolymorphism of the vascular endothelial growth factor gene and susceptibility to basal cell carcinoma – preliminary study. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 26(2), 71-73.

Chicago

Sobjanek, Michał, Monika Zabłotna, Igor Michajłowski, Marek Urban, Bogusław Nedoszytko, Wioletta Mędrzycka-Dąbrowska,  and Adam Włodarkiewicz et al. 2009. "Original papersPolymorphism of the vascular endothelial growth factor gene and susceptibility to basal cell carcinoma – preliminary study". Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii 26 (2): 71-73.

Harvard

Sobjanek, M., Zabłotna, M., Michajłowski, I., Urban, M., Nedoszytko, B., Mędrzycka-Dąbrowska, W., Włodarkiewicz, A.,  and Roszkiewicz, J. (2009). Original papersPolymorphism of the vascular endothelial growth factor gene and susceptibility to basal cell carcinoma – preliminary study. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 26(2), pp.71-73.

MLA

Sobjanek, Michał et al. "Original papersPolymorphism of the vascular endothelial growth factor gene and susceptibility to basal cell carcinoma – preliminary study." Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, vol. 26, no. 2, 2009, pp. 71-73.

Vancouver

Sobjanek M, Zabłotna M, Michajłowski I, Urban M, Nedoszytko B, Mędrzycka-Dąbrowska W et al. Original papersPolymorphism of the vascular endothelial growth factor gene and susceptibility to basal cell carcinoma – preliminary study. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2009;26(2):71-73.

Introduction: The vascular endothelial growth factor (VEGF) is involved in pathologic angiogenesis in several neoplasms. Several functional single nucleotide polymorphisms (SNPs) in the promoter region have been described. It has been suggested that -1154G/A polymorphism is associated with VEGF expression.
Aim: The aim of our study was to evaluate the connection between -1154G/A VEGF gene polymorphism and BCC susceptibility.
Material and methods: We analyzed 100 patients with BCC and 240 healthy controls. The -1154G/A polymorphism in the promoter region of the VEGF gene was analyzed by amplification refractory mutation system-polymerase chain reaction. The result was evaluated by the c2 test with Yates correction.
Results: We have found that AA genotype frequency was significantly decreased among patients with BCC in comparison with control subjects (3 vs. 16.2%, p = 0.0014). We also found that VEGF-1154 A allele frequency was significantly decreased among patients with BCC in comparison with control subjects (30.5 vs. 40.0%, p = 0.0246).
Conclusions: This is the first report concerning VEGF gene polymorphism and BCC. Presented data suggest that the SNP at position -1154 of the promoter region of the VEGF gene may play a role in pathogenesis of BCC.

keywords:

Original papersPolymorphism of the vascular endothelial growth factor gene and susceptibility to basal cell carcinoma – preliminary study

Michał Sobjanek , Monika Zabłotna , Igor Michajłowski , Marek Urban , Bogusław Nedoszytko , Wioletta Mędrzycka-Dąbrowska , Adam Włodarkiewicz , Jadwiga Roszkiewicz

VEGF, gene polymorphism, basal cell carcinoma

Original papers
Polymorphism of the vascular endothelial growth factor gene and susceptibility to basal cell carcinoma – preliminary study

Michał Sobjanek

,

Monika Zabłotna

,

Igor Michajłowski

,

Marek Urban

,

Bogusław Nedoszytko

,

Wioletta Mędrzycka-Dąbrowska

,

Adam Włodarkiewicz

,

Jadwiga Roszkiewicz