Assessment of IL-10/IL-6 ratio in differential diagnosis of primary vitreoretinal lymphoma – a case series report

Weronika Szliwa; Wojciech Adamski; Dariusz Wawrzyniak; Ewa Mizera-Nyczak; Aldona Kaczmarek; Katarzyna Rolle; Andrzej Marszałek; Iwona Rospond-Kubiak

doi:10.5114/ko.2021.104984

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ISSN: 0023-2157

Klinika Oczna / Acta Ophthalmologica Polonica

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1/2021
vol. 123

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abstract:

Original paper

Assessment of IL-10/IL-6 ratio in differential diagnosis of primary vitreoretinal lymphoma – a case series report

Weronika Szliwa

¹

,

Wojciech Adamski

¹

,

Dariusz Wawrzyniak

²

,

Ewa Mizera-Nyczak

³

,

Aldona Kaczmarek

⁴

,

Katarzyna Rolle

²

,

Andrzej Marszałek

³

,

Iwona Rospond-Kubiak

¹

Department of Ophtahlmology, Poznan University of Medical Sciences, Poland
Department of Molecular Neurooncology, Institute of Bioorganic Chemistry, Polish Academy of Science in Poznan, Poland
Department of Cancer Pathology and Prophylaxis, Greater Poland Cancer Centre, Poznan, Poland
Flow Cytometry Laboratory, Greater Poland Cancer Centre, Poznan, Poland

KLINIKA OCZNA 2021, 123, 1: 30–34

DOI: https://doi.org/10.5114/ko.2021.104984

Online publish date: 2021/03/31

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AMA

Szliwa W, Adamski W, Wawrzyniak D, et al. Assessment of IL-10/IL-6 ratio in differential diagnosis of primary vitreoretinal lymphoma – a case series report. Klinika Oczna / Acta Ophthalmologica Polonica. 2021;123(1):30-34. doi:10.5114/ko.2021.104984.

APA

Szliwa, W., Adamski, W., Wawrzyniak, D., Mizera-Nyczak, E., Kaczmarek, A.,  & Rolle, K. et al. (2021). Assessment of IL-10/IL-6 ratio in differential diagnosis of primary vitreoretinal lymphoma – a case series report. Klinika Oczna / Acta Ophthalmologica Polonica, 123(1), 30-34. https://doi.org/10.5114/ko.2021.104984

Chicago

Szliwa, Weronika, Wojciech Adamski, Dariusz Wawrzyniak, Ewa Mizera-Nyczak, Aldona Kaczmarek, Katarzyna Rolle,  and Andrzej Marszałek et al. 2021. "Assessment of IL-10/IL-6 ratio in differential diagnosis of primary vitreoretinal lymphoma – a case series report". Klinika Oczna / Acta Ophthalmologica Polonica 123 (1): 30-34. doi:10.5114/ko.2021.104984.

Harvard

Szliwa, W., Adamski, W., Wawrzyniak, D., Mizera-Nyczak, E., Kaczmarek, A., Rolle, K., Marszałek, A.,  and Rospond-Kubiak, I. (2021). Assessment of IL-10/IL-6 ratio in differential diagnosis of primary vitreoretinal lymphoma – a case series report. Klinika Oczna / Acta Ophthalmologica Polonica, 123(1), pp.30-34. https://doi.org/10.5114/ko.2021.104984

MLA

Szliwa, Weronika et al. "Assessment of IL-10/IL-6 ratio in differential diagnosis of primary vitreoretinal lymphoma – a case series report." Klinika Oczna / Acta Ophthalmologica Polonica, vol. 123, no. 1, 2021, pp. 30-34. doi:10.5114/ko.2021.104984.

Vancouver

Szliwa W, Adamski W, Wawrzyniak D, Mizera-Nyczak E, Kaczmarek A, Rolle K et al. Assessment of IL-10/IL-6 ratio in differential diagnosis of primary vitreoretinal lymphoma – a case series report. Klinika Oczna / Acta Ophthalmologica Polonica. 2021;123(1):30-34. doi:10.5114/ko.2021.104984.

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Aim of the study
To analyze the clinical applicability of interleukin 10 (IL-10) and interleukin 6 (IL-6) ratio assessment in intraocular fluids for the diagnosis of vitreoretinal lymphoma.

Material and methods
The data of the patients who underwent a diagnostic vitrectomy or anterior chamber fluid aspiration because of the clinical suspicion of vitreoretinal lymphoma at the Department of Ophthalmology, Poznan University of Medical Sciences (PUMS), between 2016 and 2019, were retrospectively reviewed. All patients underwent full ophthalmological examination including ultrasound prior to the surgery. Routine histopathology examination and flow cytometry were performed in obtained vitreous samples or aqueous humor aspirate as well as the evaluation of IL-6 and IL-10 ratio (IL-10 : IL-6) with the ELISA assay.

Results
There were 7 patients: 3 women, 4 men in the mean age of 67 years (range: 60-81 years). In 2 cases, primary vitreous involvement was suspected, and in another 5, secondary. In 4 cases DLBCL (diffuse large B-cell lymphoma) was diagnosed. In 4 patients, the IL-10/IL-6 ratio was above 1.0, in 3 others - below 1.0. The median follow-up was 23 months (range: 2-82 months). 5 lymphoma patients died 13 months after ophthalmic diagnosis due to disease progression.

Conclusions
The assessment of IL-10 and IL-6 ratio may be a valuable tool facilitating the diagnosis of vitreoretinal lymphoma in some patients.

keywords:

Assessment of IL-10/IL-6 ratio in differential diagnosis of primary vitreoretinal lymphoma – a case series report

Weronika Szliwa 1 , Wojciech Adamski 1 , Dariusz Wawrzyniak 2 , Ewa Mizera-Nyczak 3 , Aldona Kaczmarek 4 , Katarzyna Rolle 2 , Andrzej Marszałek 3 , Iwona Rospond-Kubiak 1

lymphoma, uveitis, interleukin 10, interleukin 6, vitreous biopsy

Weronika Szliwa

¹

,

Wojciech Adamski

¹

,

Dariusz Wawrzyniak

²

,

Ewa Mizera-Nyczak

³

,

Aldona Kaczmarek

⁴

,

Katarzyna Rolle

²

,

Andrzej Marszałek

³

,

Iwona Rospond-Kubiak

¹