eISSN: 2299-0046
ISSN: 1642-395X
Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii
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3/2020
vol. 37
 
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abstract:
Original paper

Assessment of auditory function and lipid levels in patients receiving oral isotretinoin (13-cis retinoid) therapy for acne vulgaris

Mahizer Yaldiz
1
,
Ahmet Kara
2
,
Mehmet Güven
2
,
Berna Solak
1
,
Rabia Kara
1
,
Mustafa Teoman Erdem
1

  1. Department of Dermatology, Training and Research Hospital, Sakarya University, Sakarya, Turkey
  2. Department of Otorhinolaryngology, Training and Research Hospital, Sakarya University, Sakarya, Turkey
Adv Dermatol Allergol 2020; XXXVII (3): 360-363
DOI: https://doi.org/10.5114/ada.2018.79566
Online publish date: 2018/11/14
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Introduction
Isotretinoin (13-cis retinoid) is a synthetic retinoid. It was approved by the FDA in 1982 for use of oral isotretinoin in severe acne. It is also used in moderate-severe acne that does not respond to conventional treatments. Isotretinoin is the only available drug that affects all stages of acne pathogenesis.

Aim
To prospectively investigate whether there is an effect of isotretinoin therapy on auditory function and, if so, to demonstrate its association with simultaneous blood lipid levels.

Material and methods
Thirty patients (60 ears) with acne vulgaris, who received 0.5 mg/kg of isotretinoin therapy, were included in the study. Distortion product otoacoustic emissions (DPOAEs) and pure tone audiometry tests were performed to evaluate auditory function at the beginning of the procedure and the 6th month of treatment. In addition, aspartate aminotransferase (AST), alanine aminotransferase (ALT), total cholesterol, triglyceride, high-density lipoproteins (HDL) and low-density lipoproteins (LDL) cholesterol levels were recorded.

Results
There was no statistically significant difference between pre-treatment and post-treatment mean pure tone audiometry threshold and DPOAE values; however, the increase in total blood cholesterol, triglyceride and LDL levels and the decrease in HDL levels were statistically significant.

Conclusions
According to our study findings, isotretinoin did not cause worsening of the bilateral hearing threshold, but increased blood lipid levels. There is no need for follow-up auditory functions in routine practice during therapy, but blood lipid levels should be monitored.

keywords:

auditory function, acne vulgaris, isotretinoin
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