Assessment of autonomic nervous system functions and cardiac rhythms in patients using isotretinoin

Halil Ay; Mustafa Aksoy; Fatih Güngören

doi:10.5114/ada.2018.76848

eISSN: 2299-0046
ISSN: 1642-395X

Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii

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abstract:

Original paper

Assessment of autonomic nervous system functions and cardiac rhythms in patients using isotretinoin

Halil Ay

¹

,

Mustafa Aksoy

²

,

Fatih Güngören

³

Department of Neurology, Harran University, Şanlıurfa, Turkey
Department of Dermatology, Harran University, Şanlıurfa, Turkey
Department of Cardiology, Harran University, Şanlıurfa, Turkey

Adv Dermatol Allergol 2019; XXXVI (3): 291–294

DOI: https://doi.org/10.5114/ada.2018.76848

Online publish date: 2018/06/29

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Aim
The aim of the study was to analyze the potential effects of isotretinoin, frequently used in the treatment of acne vulgaris these days.

Material and methods
For this purpose, we used the methods of sympathetic skin response (SSR) electrophysiological analysis and electrocardiographic (ECG) analysis in patients using isotretinoin. Thirty patients who were diagnosed with acne vulgaris and treated with oral isotretinoin with a dose of 0.5 mg/kg for at least 1 month were included in the study. In all patients ECG scanning and SSR analysis were performed both before treatment and 1 month after the start of treatment.

Conclusions
This study is very important because SSR results show that increasing the existing sympathetic activity in acne vulgaris after isotretinoin usage could explain the exacerbation in acne lesions for the first month, and according to the ECG results the medication did not cause cardiac side effects.

keywords:

Assessment of autonomic nervous system functions and cardiac rhythms in patients using isotretinoin

Halil Ay 1 , Mustafa Aksoy 2 , Fatih Güngören 3

isotretinoin, sympathetic skin response, acne vulgaris

Halil Ay

¹

,

Mustafa Aksoy

²

,

Fatih Güngören

³