Assessment of peripheral blood concentration of angiopoietin 1, angiopoietin 2 and Tie-2 (a tyrosine kinase receptor) of patients with goitre treated surgically

Joanna Kalupa; Krzysztof Kuzdak; Krzysztof Kołomecki

doi:10.5114/wiitm.2011.23212

eISSN: 2299-0054
ISSN: 1895-4588

Videosurgery and Other Miniinvasive Techniques

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2/2011
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abstract:

Original paper

Assessment of peripheral blood concentration of angiopoietin 1, angiopoietin 2 and Tie-2 (a tyrosine kinase receptor) of patients with goitre treated surgically

Joanna Kalupa

,

Krzysztof Kuzdak

,

Krzysztof Kołomecki

Videosurgery and other miniinvasive techniques 2011; 6 (2): 64 -72

DOI: https://doi.org/10.5114/wiitm.2011.23212

Online publish date: 2011/07/08

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Introduction : Blood vessel formation by angiogenesis is essential for goitre development. Angiopoietin 1 (Ang-1), angiopoietin 2 (Ang-2) and Tie-2 receptor (rTie-2) are involved in part of angiogenesis. Ang-1 and rTie-2 expression increases in goitre.

Aim : To determine serum concentrations (SC) of angiogenic cytokines of patients with goitre treated surgically.

Material and methods : Thirty-six patients with goitre aged 29-64 were examined. They were divided into groups: non-toxic nodular goitre (NTNG) and toxic goitre (TG). Each group was divided into subgroups: before and after surgery. The control group comprised 10 healthy subjects. Ang-1, Ang-2 and rTie-2 SC were measured in euthyroid subjects by ELISA. Measurements were performed before the procedure and three months after.

Results : Before surgery Ang-1 median (Me) SC in patients with TG was higher than in patients with NTNG (109 368 pg/ml vs. 71 185 pg/ml) and in controls (109 368 pg/ml vs. 57 815 pg/ml). Ang-1 Me in TG patients was higher prior to than after surgery (109 368 pg/ml vs. 65380 pg/ml). Ang-2 Me in TG patients was higher after than prior to surgery (4055 pg/ml vs. 3924 pg/ml). Significant correlations were found between Ang-1 and Tie-2 Me (r = 0.53) and Ang-2 and Tie-2 (r = 0.58) in patients with NTNG before surgery and between Me Ang-2 and Tie-2 in patients with NTNG after surgery (r = 0.89) and in controls (r = 0.77).

Conclusions : Before surgery in patients with TG SC of Ang-1 was higher than in patients with NTNG and in controls. After surgery in patients with TG SC of Ang-1 decreased, and SC of Ang-2 increased. Significant correlations were found between SC of Ang-2 and Tie-2 in patients with NTNG and in controls.

keywords:

Assessment of peripheral blood concentration of angiopoietin 1, angiopoietin 2 and Tie-2 (a tyrosine kinase receptor) of patients with goitre treated surgically

Joanna Kalupa , Krzysztof Kuzdak , Krzysztof Kołomecki

angiogenesis, angiopoietin 1, angiopoietin 2, Tie-2 receptor, goitre

Joanna Kalupa

,

Krzysztof Kuzdak

,

Krzysztof Kołomecki