Assessment of the diagnostic usefulness of liquid-based cytology. The impact of modifications

Andrzej Marszałek; Joanna Bakinowska; Małgorzata Grobelna; Adam Śliwiński

doi:10.5114/pjp.2023.134320

eISSN: 2084-9869
ISSN: 1233-9687

Polish Journal of Pathology

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4/2023
vol. 74

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abstract:

Original paper

Assessment of the diagnostic usefulness of liquid-based cytology. The impact of modifications

Andrzej Marszałek

^{1, 2}

,

Joanna Bakinowska

¹

,

Małgorzata Grobelna

¹

,

Adam Śliwiński

¹

Department of Tumor Pathology, The Greater Poland Cancer Centre, Poznań, Poland
Department of Tumor Pathology and Prophylaxis, University of Medical Sciences, Poznañ, Poland

Pol J Pathol 2023; 74 (4): 271-281

DOI: https://doi.org/10.5114/pjp.2023.134320

Online publish date: 2024/02/01

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The technique of liquid-based cytology (LBC) is of increasing diagnostic value in non-gynecological cytology. The purpose of the present study was to validate modifications to stages of the LBC process and to assess the diagnostic usefulness of the LBC technique.

Between May 2021 and January 2022, a total of 484 samples were prepared from routine cytology tests carried out in the Department of Tumor Pathology of The Greater Poland Cancer Center. The material was obtained from fine-needle aspiration biopsies and fluid samples. One hundred cases were selected for the research described in the article. The slides were prepared using the Becton Dickinson Totalys SlidePrep device.

Based on the research, it was concluded that predominantly the LBC technique gives better results than a conventional smear because the background, which would otherwise make it difficult to assess preparations, was eliminated. Additionally, in LBC preparations the cellularity was increased, and the cells were arranged in a monolayer system, which improves the image quality. The introduction of modifications to the LBC method facilitated the process of sample preparation, without adversely affecting the quality of the obtained material.

keywords:

Assessment of the diagnostic usefulness of liquid-based cytology. The impact of modifications

Andrzej Marszałek 1, 2 , Joanna Bakinowska 1 , Małgorzata Grobelna 1 , Adam Śliwiński 1

liquid-based cytology (LBC), SurePath, non-gynecological cytology, fluid from body cavities, fine-needle aspiration (FNA)

Andrzej Marszałek

^{1, 2}

,

Joanna Bakinowska

¹

,

Małgorzata Grobelna

¹

,

Adam Śliwiński

¹