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eISSN: 2084-9869
ISSN: 1233-9687
Polish Journal of Pathology
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Case report

Assessment of the status of DNA mismatch repair proteins by immunohistochemistry. Proposal for evaluation with two antibodies

Leonardo Saul Lino-Silva
1
,
Ángeles Galán-Ramírez
1
,
Sabrina B Martínez-Villavicencio
2
,
Luisa Rivera-Moncada
2
,
César Zepeda-Najar
3
,
Hanna I Ortega-Martínez
2

  1. Instituto Nacional De Cancerologia De Mèxico, Mexico City, Mexico
  2. AFINES program, Medicine Faculty, National Autonomous University of Mexico (UNAM), Coyoacan, Mexico City, Mexico
  3. Hospital Angeles Tijuana, Tijuana, Baja California Norte, Mexico
Pol J Pathol 2025; 76 (1)
Online publish date: 2025/03/13
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1. Eikenboom EL, van der Werf-’t Lam AS, Rodríguez-Girondo M, et al. Universal Immunohistochemistry for Lynch syndrome: a systematic review and meta-analysis of 58,580 colorectal carcinomas. Clin Gastroenterol Hepatol 2022; 20: e496-e507.
2. Li Y, Tian S, Ran J, Han X. Lowered expression level of INSC predicts poor prognosis in patients with colon cancer. Pol J Pathol 2023; 74: 109-121.
3. Zhao X, Chen Y, Wang L, Sui D, Lu J. Prognosis poor, immune infiltration of colon adenocarcinoma associated with low expression levels of calcium-activated chloride channel. Pol J Pathol 2024; 75: 138-152.
4. Samowitz WS, Curtin K, Lin HH, et al. The colon cancer burden of genetically defined hereditary nonpolyposis colon cancer. Gastroenterology 2001; 121: 830-838.
5. Haron NH, Mohamad Hanif EA, Abdul Manaf MR, et al. Microsatellite instability and altered expressions of MLH1 and MSH2 in gastric cancer. Asian Pac J Cancer Prev 2019; 20: 509-517.
6. Aiyer KTS, Doeleman T, Ryan NA, et al. Validity of a two-antibody testing algorithm for mismatch repair deficiency testing in cancer; a systematic literature review and meta-analysis. Mod Pathol 2022; 35: 1775-1783.
7. Luchini C, Bibeau F, Ligtenberg MJL, et al. ESMO recommendations on microsatellite instability testing for immunotherapy in cancer, and its relationship with PD-1/PD-L1 expression and tumour mutational burden: a systematic review-based approach. Ann Oncol 2019; 30: 1232-1243.
8. Colon and rectum biomarker reporting, College of American Pathologists. Available from: https://documents.cap.org/protocols/ColoRectal.Bmk_1.3.0.0.REL_CAPCP.pdf?_gl=1*20ehoq*_ga*MjEzMzc5MzcxMi4xNjkyODk0MDIy*_ga_97ZFJSQQ0X*MTY5Mjg5NDAyMS4xLjAuMTY5Mjg5NDAyOS4wLjAuMA. Access verified august 2023.
9. Hanley JA, McNeil BJ. The meaning and use of the area under a receiver operating characteristic (ROC) curve. Radiology 1982; 143: 29-36.
10. Eso Y, Shimizu T, Takeda H, Takai A, Marusawa H. Microsatellite instability and immune checkpoint inhibitors: toward precision medicine against gastrointestinal and hepatobiliary cancers. J Gastroenterol 2020; 55: 15-26.
11. Lee CT, Chow NH, Chen YL, et al. Clinicopathological features of mismatch repair protein expression patterns in colorectal cancer. Pathol Res Pract 2021; 217: 153288.
12. Chen L, Chen G, Zheng X, Chen Y. Expression status of four mismatch repair proteins in patients with colorectal cancer: clinical significance in 1238 cases. Int J Clin Exp Pathol 2019; 12: 3685-3699.
13. Battaglin F, Naseem M, Lenz HJ, Salem ME. Microsatellite instability in colorectal cancer: overview of its clinical significance and novel perspectives. Clin Adv Hematol Oncol 2018; 16: 735-745.
14. Martínez-Roca A, Giner-Calabuig M, Murcia O, et al. Lynch-like syndrome: potential mechanisms and management. Cancers (Basel) 2022; 14: 1115.
15. Cheah PL, Looi LM, Horton S. Cost analysis of operating an anatomic pathology laboratory in a middle-income country. Am J Clin Pathol 2017; 149: 1-7.
16. Neil A, Pfeffer S, Burnett L. Benchmarking in pathology: developing a benchmarking complexity unit and associated key performance indicators. Pathology 2013; 45: 66-70.
Copyright: © 2025 Polish Association of Pathologists and the Polish Branch of the International Academy of Pathology This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
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