Association between gastrointestinal symptoms and disease severity in patients with COVID-19 in Tehran City, Iran

Elena Lak; Seyed Sheikholeslami; Mahmoud Ghorbi; Mostafa Shafei; Homayon Yosefi

doi:10.5114/pg.2021.106245

eISSN: 1897-4317
ISSN: 1895-5770

Gastroenterology Review/Przegląd Gastroenterologiczny

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1/2022
vol. 17

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abstract:

Original paper

Association between gastrointestinal symptoms and disease severity in patients with COVID-19 in Tehran City, Iran

Elena Lak

¹

,

Seyed Amir Sheikholeslami

²

,

Mahmoud Dehghani Ghorbi

³

,

Mostafa Shafei

⁴

,

Homayon Yosefi

⁵

Department of Gastroenterology, School of Medicine, Imam Hossein Hospital Shahid Beheshti University of Medical Science, Tehran, Iran
Department of Adult Haematology and Oncology, School of Medicine, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Department of Haematology and Oncology, School of Medicine, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
School of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Department of Oncology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Gastroenterology Rev 2022; 17 (1): 52–58

DOI: https://doi.org/10.5114/pg.2021.106245

Online publish date: 2021/05/18

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Introduction
It is important to identify the relationship between COVID-19 and gastrointestinal symptoms for health organizations in different communities. Aim: To assess the relationship between gastrointestinal symptoms and COVID-19.

Material and methods
It was a cross-sectional descriptive-analytical study that was conducted on 381 patients those where admitted to Imam Hossein Hospital with a confirmed diagnosis of COVID-19 on nasopharyngeal polymerase chain reaction testing for SARS-CoV-2 from first March to end of June in Tehran city; 2020. Data was entered and analyzed by using SPSS version 22 and level of significant was consider less than 0.05.

Results
Out of all the patients with COVID-19, 164 (43%) had gastrointestinal symptoms. The most symptoms of them were nausea (19.2%), vomiting (17.2%), abdominal pain (15.7%), diarrhoea (12.6%), haematomas (1%), melena (1.6%), rectal bleeding (1.6%), and constipation (1.8%), respectively. The mean D-dimer1 value was significantly different between the 2 groups with gastrointestinal symptoms and no gastrointestinal symptoms. In other words, there is a strong relationship between the variable D-dimer1, which is one of the important symptoms showing the severity of COVID-19 disease, and gastrointestinal symptoms (p < 0.0001).

Conclusions
Our finding shows a statistical relationship between the level of D-dimer and gastrointestinal symptoms in patients with COVID-19. The mortality rate was higher in patients with gastrointestinal symptoms, which is an important outcome for gastroenterologists.

keywords:

Association between gastrointestinal symptoms and disease severity in patients with COVID-19 in Tehran City, Iran

Elena Lak 1 , Seyed Amir Sheikholeslami 2 , Mahmoud Dehghani Ghorbi 3 , Mostafa Shafei 4 , Homayon Yosefi 5

gastrointestinal symptom, COVID-19, Iran

Elena Lak

¹

,

Seyed Amir Sheikholeslami

²

,

Mahmoud Dehghani Ghorbi

³

,

Mostafa Shafei

⁴

,

Homayon Yosefi

⁵